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WM microstructural abnormalities and cognitive impairment in MDD: TBSS study

Research Project

Project/Area Number 17K16396
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionWakayama Medical University

Principal Investigator

Shinichi Yamada  和歌山県立医科大学, 医学部, 助教 (70549716)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords気分障害 / 白質微細構造異常 / 認知機能障害 / うつ病 / 脳部位間結合 / 認知機能 / 老年期うつ病 / 認知症 / 拡散テンソル画像 / 安静時fMRI
Outline of Final Research Achievements

Fractional anisotropy of white matter in widespread regions in the patient groups was significantly reduced compared with that in the healthy controls. In voxels where fractional anisotropy was significantly lower in the major depressive disorder group compared to in the healthy controls, the fractional anisotropy in the corpus callosum and the right cingulum were significantly related with the z scores of attention and cognitive composite scores. Our results support that a common neurobiological mechanism exists across these three disorders and that white matter abnormalities are related to cognitive impairment in major depressive disorder.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は、気分障害では白質神経線維の微細構造という解剖学的なレベルの異常が存在し、特異的な認知領域と関連していることを示唆する。
近年は神経ネットワークを評価する神経画像手法(DTIや安静時機能的MRI(rs-fMRI))が発展してきた。将来的にはDTIとrs-fMRIによる解析の手法を用いて、統合失調症や気分障害などの精神疾患に見られる神経ネットワークの特徴、アルツハイマーなど認知症に特徴的な神経ネットワークを明らかにし、多疾患で臨床症状と結びつけることで疾患横断的な生物学的指標を確立し、従来の症状評価に基づいた診断体系をブレイクスルーする契機としたい。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2020 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Widespread white matter microstructural abnormalities and cognitive impairment in schizophrenia, bipolar disorder, and major depressive disorder: Tract-based spatial statistics study2020

    • Author(s)
      Yamada S, Takahashi S, Ohoshi Y, Ishida T, Tsuji T, Shinosaki K, Terada M, Ukai S
    • Journal Title

      Psychiatry Res Neuroimaging

      Volume: 298 Pages: 111045-111045

    • DOI

      10.1016/j.pscychresns.2020.111045

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] WM abnormalities and their relationship with cognitive impairment in SZ, BD, and MDD2020

    • Author(s)
      Shinichi Yamada, Shun Takahashi, Takuya Ishida, Yuji Ohoshi, Tomikimi Tsuji, Masaki Terada, Satoshi Ukai
    • Organizer
      2020 OHBM ANNUAL MEETING
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Widespread white matter microstructural abnormalities related to cognitive impairment in schizophrenia, bipolar disorder, and major depressive disorder: A tract-based spatial statistics study2018

    • Author(s)
      7. Shinichi Yamada, Shun Takahashi, Takuya Ishida, Yuji Ohoshi, Tomikimi Tsuji, Masaki Terada, Satoshi Ukai.
    • Organizer
      The 11th Annual Scientific Meeting Hong Kong Society of Biological Psychiatry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Widespread white matter microstructural abnormalities and their relationship with age in schizophrenia, bipolar disorder, and major depressive disorder.2018

    • Author(s)
      10. Shinichi Yamada, Shun Takahashi, Takuya Ishida, Yuji Ohoshi, Tomikimi Tsuji, Masaki Terada, Satoshi Ukai.
    • Organizer
      The World Federation of Societies of Biological Psychiatry 2018 KOBE
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合失調症と気分障害における白質微細構造異常と認知機能障害との関係: DTI研究2017

    • Author(s)
      山田信一、高橋隼、石田卓也、大星裕司、寺田正樹、篠崎和弘、鵜飼聡
    • Organizer
      第39回 日本生物学的精神医学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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