MRI and computational study on fluid dynamics of cerebrospinal fluid flow and mechanisms of normal pressure hydrocephalus.

• Project/Area Number: 17K16414
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: Kamada Hiroki 東北大学, 大学病院, 医員 (00789836)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MRI / 3D cine PC MRI / CFD / 脳脊髄液流れ / 血流 / 脳脊髄液 / 正常圧水頭症 / 放射線科学 / 核磁気共鳴画像（MRI) / 流体工学

Outline of Final Research Achievements

3D cine phase contrast (PC) MRI was performed for cerebrospinal fluid (CSF) flow. A pulsatile CSF flow inter-ventricle was observed. Since the flow velocity in the ventricle was quite low, it could not be distinguished from signal noise. Thus, we carried out hemodynamic analysis of large vessel diseases such as aortic valve stenosis and pulmonary hypertension by use of 3D cine PC MRI and computational fluid dynamics. It is revealed that blood flow increased after surgical or intervention therapy, achieving effective blood transport to the distal organ.

Academic Significance and Societal Importance of the Research Achievements

非侵襲な画像診断法であるMRIや流体シミュレーションを融合させることで、生理流体の流体解析が可能となった。本研究では、脳脊髄液の動態生理を探求することはできなかったが、大血管を対象とした血流解析では、病的状態での血流や治療前後の変化を明らかにすることができた。本研究で用いた手法は、血流が関連する様々な疾患の病態理解や治療効果評価のために、有用かつ重要な手段であると考えられた。

Research Products

• [Journal Article] Perioperative Hemodynamic Changes in the Thoracic Aorta in Patients With Aortic Valve Stenosis: A Prospective Serial 4D-Flow MRI Study. (2020)
  • Author(s): Kamada H, Ota H, Nakamura M, Imai Y, Ishida S, Sun W, Sakatsume K, Yoshioka I, Saiki Y, Takase K
  • Journal Title: Semiars in Thoracic and Cardiovascular Surgery Volume: Spring;32(1) Issue: 1 Pages: 25-34
  • DOI: 10.1053/j.semtcvs.2019.07.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 4D-flow MRI assessment of blood flow before and after endovascular intervention in a patient with pulmonary hypertension due to isolated pulmonary artery involvement in large vessel vasculitis (2019)
  • Author(s): Kamada H, Ota H, Aoki T, Sugimura K, Yaoita N, Shimokawa H, Takase K.
  • Journal Title: Radiology Case Report Volume: 15(3) Issue: 3 Pages: 190-194
  • DOI: 10.1016/j.radcr.2019.11.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Postoperative changes in volume flow rate in the thoracic aorta and the aortic arch branches in patients with aortic valve stenosis: a prospective serial 4D flow MRI study (2018)
  • Author(s): Hiroki Kamada, Hideki Ota, Masanori Nakamura, Yohsuke Imai, Wenyu Sun, Yoshiaki Komori, Ko Sakatsume, Yoshikatsu Saiki, and Kei Takase
  • Organizer: International Society for Magnetic Resonance in Medicine 2018
  • Int'l Joint Research
• [Presentation] Perioperavite hemodynamic changes in the patient with pulmonary arterial hypertension by use of thoracic 4D-flow MRI. (2018)
  • Author(s): Hiroki Kamada, Hideki Ota, Yohsuke Imai, Masanori Nakamura, and Kei Takase
  • Organizer: 8th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Postoperative changes in volume flow rate in the thoracic aorta and the aortic arch branches in patients with aortic valve stenosis: a prospective serial 4D flow MRI study (2018)
  • Author(s): Hiroki Kamada, Hideki Ota, Masanori Nakamura, Yohsuke Imai, Wenyu Sun, Yoshiaki Komori, Ko Sakatsume, Yoshikatsu Saiki, Kei Takase
  • Organizer: International Society for Magnetic Resonance in Medicine 2018
  • Int'l Joint Research
• [Presentation] Perioperavite hemodynamic changes in the patient with pulmonary arterial hypertension by use of thoracic 4D-flow MRI. (2018)
  • Author(s): Hiroki Kamada, Hideki Ota, Yohsuke Imai, Kei Takase
  • Organizer: 8th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] A case of pulmonary hypertension caused by isolated large-vessel vasculitis in proximal pulmonary arteries: imaging and intervention (2017)
  • Author(s): Hiroki Kamada, ,Hideki Ota, Nobuhiro Yaoita, Tatsuo Aoki, Koichiro Sugimura, Kentaro Takanami, Kei Takase
  • Organizer: 第85回日本心臓血管放射線研究会/ASCI2017
  • Int'l Joint Research