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Establishment of imaging and evaluation method of T1rho MRI for preoperative imaging diagnosis of glioma

Research Project

Project/Area Number 17K16415
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

Akashi Toshiaki  東北大学, 医学系研究科, 非常勤講師 (40623492)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords神経膠腫 / T1rho / MRI / 定量 / 脳 / IDH-1 / ATRX / 画像診断 / 脳神経疾患
Outline of Final Research Achievements

Since T1rho MRI for preoperative imaging diagnosis of glioma takes time during imaging acquisition, we examined R1rho '(m), which is the difference between the reciprocals of T1rho and T2. It took 10 minutes to measure T1rho and T2, but it was possible to shorten it to 2 minutes by substituting R1rho´ (80). In addition, T1rho showed some correlation with the results of immunohistochemical staining of IDH-1 and ATRX in malignant glioma.

Academic Significance and Societal Importance of the Research Achievements

神経膠腫の術前画像診断のためのT1rho MRIは悪性神経膠腫においてIDH-1およびATRXの免疫科学組織染色の結果とある程度相関が見られ、遺伝子変異の予測に寄与することが示唆された。ただし、T1rho MRIの撮像には時がかかるため,T1rhoとT2の逆数の差分であるR1rho´の測定について検討した.T1rhoとT2の測定によるR1rho´(m)の算出には10分かかるが,R1rho´(80)で代用することで2分に短縮することが可能となった.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Quantitative T1rho measurement of gliomas2018

    • Author(s)
      Toshiaki Akashi
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] T1rho of Malignant Gliomas can be a Biomarker of IDH1 and ATRX Immunohistochemical Stainability.2018

    • Author(s)
      Toshiaki Akashi
    • Organizer
      The Radiological Society of North America 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経膠腫におけるT1rhoと病理学的所見の検討2018

    • Author(s)
      明石敏昭
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 神経膠腫におけるT1rho緩和の検討2017

    • Author(s)
      明石敏昭
    • Organizer
      日本医学放射線学会北日本地方会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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