Establishment of a new diagnostic method for primary aldosteronism using Metomidate.
| Project/Area Number |
17K16417
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 核医学 / PET / 副腎 / 原発製アルドステロン症 / 膵臓癌 / FDG / 膵腫瘍 / 副腎腺腫 / 原発性アルドステロン症 / 11C-Metomidate / 放射線 |
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| Outline of Final Research Achievements |
In collaboration with the Cyclotron Radioisotope Center, Tohoku University, we established the synthesis of 11C-Metomidate. 11C-Metomidate was also subjected to autoradiography using tissue samples from human adrenal adenomas. 11C-Metomidate also accumulated more strongly in the marginal adrenal tissue than in the internal aldosterone-producing adenoma. Animal administration experiments were conducted and imaging was performed with animal PET/CT. The distribution of 11C- metomidate in the body was measured using mice, and the exposure dose values were obtained by converting the data to those for humans.
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| Academic Significance and Societal Importance of the Research Achievements |
平成29年、日本医学放射線学会にて「副腎のPET imaging」の教育演題を発表し、優秀演題賞を受賞した。PETを用いた副腎の画像診断について広く周知することができた。また、研究結果を複数の論文雑誌に投稿し、掲載されることで国際的に広く周知することができた。
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Report
(7 results)
Research Products
(9 results)
