| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In collaboration with the Cyclotron Radioisotope Center, Tohoku University, we established the synthesis of 11C-Metomidate. 11C-Metomidate was also subjected to autoradiography using tissue samples from human adrenal adenomas. 11C-Metomidate also accumulated more strongly in the marginal adrenal tissue than in the internal aldosterone-producing adenoma. Animal administration experiments were conducted and imaging was performed with animal PET/CT. The distribution of 11C- metomidate in the body was measured using mice, and the exposure dose values were obtained by converting the data to those for humans.
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