| Project/Area Number |
17K16422
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 前立腺癌 / 去勢抵抗性前立腺癌 |
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| Outline of Final Research Achievements |
Although hormone therapy is effective for prostate cancer, its effectiveness is lost over time and become castration-resistant prostate cancer. It has been suggested that castration resistant prostate cancer is also resistant to X-rays generally used for radiation therapy. Using a hormone-sensitive cell line and a castration-resistant cell model prepared therefrom, heavy ion beam showed that castration-resistant cells had no difference in effect from hormone-sensitive cells. In addition, analysis of DNA revealed its causative gene, and comprehensive analysis of RNA identified candidate molecular mechanisms that could cause X-ray resistance.
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| Academic Significance and Societal Importance of the Research Achievements |
日本における前立腺癌の罹患率は増加しており、ホルモン療法への感受性が失われた去勢抵抗性前立腺癌ではX線治療にも抵抗性となるために有効な治療法が確立しておらず、医学的、社会的な課題となっている。今回の研究では、去勢抵抗性前立腺癌での重粒子線治療の有効性について基礎的な結果を示し、また、その原因となるメカニズムの候補を示したことにより、去勢抵抗性前立腺癌の放射線治療抵抗性の克服につながり、今後の治療法確立の一助となることが期待される。
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