Study on tissue specific biological effectiveness of carbon-ion beam

Research Project

Project/Area Number	17K16437
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Osaka University
Principal Investigator	Yagi Masashi 大阪大学, 医学系研究科, 寄附講座助教 (40737491)
Project Period (FY)	2017-04-01 – 2021-03-31
Project Status	Completed (Fiscal Year 2020)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	粒子線治療 / 炭素線生物学的効果 / 医学物理（学）
Outline of Final Research Achievements	This study performed a fundamental research of a tissue specific biological effect of carbon-ion beam for a carbon-ion beam dose calculation by acquiring tissue specific biological characteristics which were not revealed at this moment. Our study showed a large heterogeneity of the relative biological effectiveness of various tumor cell lines and normal tissue cell lines in carbon-ion. The results suggest that tumor and normal tissue specific dose optimization, calculation and evaluation are necessary for carbon-ion therapy.
Academic Significance and Societal Importance of the Research Achievements	炭素線の生物学的効果は全ての腫瘍に対して、１つの特定の癌細胞の生物学的効果のみが反映されている。しかし、炭素線の生物学的効果は腫瘍の種類によって異なることが示唆されている。炭素線の生物学的効果の組織による違いを示すことで、個々の組織に適した過不足のない炭素線治療を行うことができ、炭素線治療の更なる腫瘍制御率の向上及び有害事象発生率の低下が期待できる。