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Influence of different CT and MRI contrast materials on the induction of DNA damage

Research Project

Project/Area Number 17K16444
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionHiroshima University

Principal Investigator

Fukumoto Wataru  広島大学, 医系科学研究科(医), 特任助教 (00726870)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsDNA損傷 / 造影剤 / CT / DNA / 被爆
Outline of Final Research Achievements

The purpose of this study was to assess the influence of different CT and MRI contrast materials on the induction of DNA damage in vitro and vivo study.
Our results confirmed that iodinated contrast materials enhanced CT-induced DNA damage. However, there was no significant difference in the enhancement of DNA damage between different CT and MRI contrast materials.

Academic Significance and Societal Importance of the Research Achievements

CTは、現代医療において最も重要な検査のひとつであるが、放射線を使用するため、生物学的影響について関心が高まっている。最近の報告では、1回のCT撮影でもDNA損傷が生じるとされているが、造影剤を使用することにより、DNA損傷が増幅されるとも報告されている。しかしながら、造影剤の違いがDNA損傷に与える影響については明らかにはなっていないのが現状である。
今回の我々の研究では、造影剤の違いによるDNA損傷の変化は認められなかった。今後、造影剤の選択を行う上で重要な結果であると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Influence of different iodinated contrast material on the induction of DNA damage by cardiac CT2019

    • Author(s)
      H.Sakane, W.Fukumoto, et al.
    • Organizer
      Radiological Society of North America (RSNA) 2019 Annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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