Evaluation of normal organs tolerance dose including individual radiosensitivity for chemoradiotherapy in esophageal cancer patients

• Project/Area Number: 17K16447
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hiroshima University
• Principal Investigator: Nishibuchi Ikuno 広島大学, 病院(医), 講師 (70595834)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 食道癌 / 化学放射線療法 / 放射線感受性 / DNA損傷 / 放射線

Outline of Final Research Achievements

Traditionally, the prediction of adverse events due to radiotherapy has been based on radiation dose and extent, and individual radiosensitivity has not been taken into account. In this study, we measured DNA damage and chromosome aberrations in lymphocytes of esophageal cancer patients undergoing chemoradiotherapy and examined the relationship between the temporal changes in DNA damage and chromosome aberrations and individual radiosensitivity and adverse events.
The results showed that the number of chromosome aberrations varied among individuals and that the number of aberrations was significantly increased in patients who developed severe acute non-hematologic toxicity. The number of chromosome aberrations may be a predictive marker for the occurrence of adverse events, suggesting that it is useful for the completion of tolerable dose assessment of normal tissues based on their sensitivity.

Academic Significance and Societal Importance of the Research Achievements

近年の高精度放射線治療技術の進歩により、腫瘍組織への線量を担保しながら、周囲正常組織への線量を低減することが可能となっている。しかしながら、正常組織の耐容線量は個々の患者の放射線感受性によらず一定とみなして、放射線治療計画を行っているのが現状である。
本研究により、照射により生じる染色体異常数と有害事象には相関がある可能性が示唆された。個々の患者の染色体異常数を評価することにより、それぞれの放射線感受性に応じた線量制約を設けることが可能となれば、より安全に化学放射線療法が施行できるようになるものと考える。

Research Products

• [Journal Article] Effectiveness of salvage radiotherapy for superficial esophageal cancer after noncurative endoscopic resection (2020)
  • Author(s): Nishibuchi I, Murakami Y, Adachi Y, Imano N, Takeuchi Y,Tkahashi I, Kimura T, Urabe Y, Oka S, Tanaka S, Nagata Y
  • Journal Title: Radiat Oncol Volume: 15 Issue: 1 Pages: 133-133
  • DOI: 10.1186/s13014-020-01582-8
  • Peer Reviewed / Open Access
• [Journal Article] Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients (2020)
  • Author(s): Imano Nobuki、Nishibuchi Ikuno、Kawabata Emi、Kinugasa Yasuha、Shi Lin、Sakai Chiemi、Ishida Mari、Sakane Hiroaki、Akita Tomoyuki、Ishida Takafumi、Kimura Tomoki、Murakami Yuji、Tanaka Kimio、Horikoshi Yasunori、Sun Jiying、Nagata Yasushi、Tashiro Satoshi
  • Journal Title: Radiation Research Volume: 195 Issue: 3 Pages: 244-252
  • DOI: 10.1667/rade-20-00234.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Novel index to predict non-hematologic acute toxicities caused by chemoradiotherapy in esophageal cancer patients. (2020)
  • Author(s): Imano N, Nishibuchi I, Kameoka T, Ochi M, Takeuchi Y, Takahashi I, Kimura T, Murakami Y, Tashiro S, Nagata Y
  • Organizer: 第79回日本医学放射線学会総会
• [Presentation] 食道癌化学放射線療法の有害事象とDNA 損傷の関連 (2020)
  • Author(s): 今野 伸樹、西淵 いくの、川端 絵美、衣笠 泰葉、坂井 千恵美、石田 万里、永田 靖、田代 聡
  • Organizer: 第45 回中国地区放射線影響研究会
• [Presentation] 高齢者に対する食道癌根治的放射線療法の治療方針とG8スコアの関連 (2020)
  • Author(s): 西淵 いくの, 村上 祐司, 石原 聡一郎, 植田 太朗, 樺山 翔平, 久保 克麿, 今野 伸樹, 竹内 有樹, 木村 智樹, 永田 靖
  • Organizer: 日本放射線腫瘍学会第33回学術大会
• [Presentation] Association between acute toxicities of chemoradiotherapy and chromosomal aberrations in peripheral blood lymphocytes in esophageal cancer patients (2020)
  • Author(s): Imano N, Nishibuchi I, Kawabata E, Kinugasa Y, Sakai C, Ishida M, Akita T, Kimura T, Murakami Y, Nagata Y, Tashiro S
  • Organizer: ASTRO 2020 (American Society for Therapeutic Radiology and Oncology 62nd the Annual Meeting)
  • Int'l Joint Research
• [Presentation] Temporal change and risk factor of esophageal stenosis after salvage radiotherapy for superficial esophageal cancer with non-curative endoscopic submucosal dissection (2020)
  • Author(s): Nishibuchi I, Murakami Y, Kameoka T, Ochi M, Imano N, Takeuchi Y, Takahashi I, Kimura T, Nagata Y
  • Organizer: ASTRO 2020 (American Society for Therapeutic Radiology and Oncology 62nd the Annual Meeting)
  • Int'l Joint Research
• [Presentation] 切除可能局所進行食道癌に対する予防領域照射を用いた根治的化学放射線療法の長期成績 (2020)
  • Author(s): 西淵 いくの、村上 祐司、亀岡 翼、越智 雅則、今野 伸樹、竹内 有樹、高橋 一平、木村 智樹、永田 靖
  • Organizer: 第74回日本食道学会学術集会
• [Presentation] Association between acute toxicities of chemoradiotherapy and chromosomal aberrations in peripheral blood lymphocytes in esophageal cancer patients. (2020)
  • Author(s): Nobuki Imano, Ikuno Nishibuchi, Emi Kawabata, Yasuha Kinugasa, Chiemi Sakai, Mari Ishida, Tomoyuki Akita, Tomoki Kimura, Yuji Murakami, Yasushi Nagata, and Satoshi Tashiro
  • Organizer: American Society for Radiation Oncology 62nd annual meeting
  • Int'l Joint Research
• [Presentation] Analysis of Chromosomal aberrations and γH2AX foci in peripheral blood lymphocytes induced by chemoradiotherapy of patients with esophageal cancer. (2019)
  • Author(s): Nobuki Imano, Lin Shi, Ikuno Nishibuchi, Yoshinori Adachi, Yuki Takeuchi, Ippei Takahashi, Tomoki Kimura, Yuji Murakami, Kentaro Miki, Akito Saito, Satoshi Tashiro, Yasushi Nagata
  • Organizer: American Society for Radiation Oncology 61st annual meeting
  • Int'l Joint Research
• [Presentation] 食道癌化学放射線療法の有害事象予測指標としての末梢血リンパ球DNA損傷と染色体異常の検討 (2019)
  • Author(s): 今野伸樹、西淵いくの、亀岡翼、越智雅則、竹内有樹、高橋一平、木村智樹、村上祐司、時林、田代聡、永田靖
  • Organizer: 日本放射線腫瘍学会第32回学術大会