| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Traditionally, the prediction of adverse events due to radiotherapy has been based on radiation dose and extent, and individual radiosensitivity has not been taken into account. In this study, we measured DNA damage and chromosome aberrations in lymphocytes of esophageal cancer patients undergoing chemoradiotherapy and examined the relationship between the temporal changes in DNA damage and chromosome aberrations and individual radiosensitivity and adverse events.
The results showed that the number of chromosome aberrations varied among individuals and that the number of aberrations was significantly increased in patients who developed severe acute non-hematologic toxicity. The number of chromosome aberrations may be a predictive marker for the occurrence of adverse events, suggesting that it is useful for the completion of tolerable dose assessment of normal tissues based on their sensitivity.
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