The evaluation of the activity using 18F-FLT PET in cardiac sarcoidosis
| Project/Area Number |
17K16450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 心臓サルコイドーシス / PET / FLT / FLT PET/CT / FLT PET / サルコイドーシス / 18F-FDG / 18F-FLT / 心サルコイドーシス |
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| Outline of Final Research Achievements |
In the present study, we evaluated the feasibility of PET study using fluorothymidine (FLT), which is a derivative of thymidine, and compared with conventional FDG PET in patients with cardiac sarcoidosis. The FLT accumulation of both cardiac and extra-cardiac lesions was significantly lower than those of FDG accumulation. However, the accuracy of FLT PET was comparable to FDG PET as for diagnosing cardiac sarcoidosis. Furthermore, The FLT accumulation of both cardiac and extra-cardiac lesions after therapy were lower than those of before therapy.
The present study indicates that FLT PET, even without the usually necessary preparation, could have the potential to diagnose cardiac sarcoidosis and identify the therapeutic response in patients with cardiac sarcoidosis.
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| Academic Significance and Societal Importance of the Research Achievements |
現在、日常診療における心臓サルコイドーシスの核医学画像診断としては、FDG PETが行われており、その有用性が知られている。しかしながら、心筋にはFDGの生理的集積があるため、検査前の長時間絶食や低炭水化物食などの厳格な前処置が必要である。FLTは心筋の生理的集積が乏しいため、前処置が不要であり、かつ生理的集積による偽病変が乏しい点で有用である。
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Report
(5 results)
Research Products
(20 results)
