| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
We retrospectively assessed patients who had received palliative radiotherapy. The absolute volume of bone marrow that had received 5, 10, 20, and 30 Gy was recorded. Overall, hematologic toxicity (white blood cell, absolute neutrophil count, and platelet) was relatively mild. No bone marrow dose-volume parameter was a significant predictor of hematologic toxicity of grade 2 or higher. Many patients experienced lymphopenia of grade 3 or higher. These findings indicate the high sensitivity of lymphocyte to irradiation.
Patients with esophageal cancer who had received definitive chemoradiotherapy at our Institution were retrospectively assessed. Spleen dose-volume parameters (V5, V10, V20, V30, and mean splenic dose) were significant independent factors negatively influencing the absolute lymphocyte count at nadir. Higher spleen dose-volume parameters were associated with severe lymphopenia during radiotherapy.
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