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Optimization of image quality and target position accuracy for four-dimensional cone-beam computed tomography

Research Project

Project/Area Number 17K16459
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKumamoto University

Principal Investigator

Shimohigashi Yoshinobu  熊本大学, 病院, 主任診療放射線技師 (60771110)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords4次元コーンビームCT / 体幹部定位放射線治療 / 画質改善 / 位置照合精度 / 最適化 / 4D-CBCT / Intreatment-4D-CBCT / 胃MLAT / PTVマージン / In-treatment 4D-CBCT / 定位放射線治療 / 画像再構成 / 画像再構成法 / 4次元コーンビームCT / IGRT / 逐次近似法 / 位置照合
Outline of Final Research Achievements

In this study, the image qualities of 4D cone-beam CT (CBCT) images obtained using various gantry rotation speeds (GRSs) for stereotactic body radiation therapy (SBRT) were quantitatively evaluated. Our findings suggest that GRSs of 67 and 85°/min are optimal selections in terms of image quality, acquisition time, and positional errors for 4D-CBCT-based image guidance. Moreover, the image quality of in-treatment 4D-CBCT (In-4D-CBCT) obtained with various prescription doses were quantitatively evaluated in volumetric modulated arc therapy (VMAT) for SBRT of the lungs and liver. We concluded that the image quality of In-4D-CBCT degraded compared with the reference image; however, it was sufficiently accurate for assessing the tumor position in VMAT for SBRT of the lungs and liver both in terms of the target volume similarity and accuracy of the fiducial marker position.

Academic Significance and Societal Importance of the Research Achievements

本研究による高精度な腫瘍位置照合の実現は、体幹部定位放射線治療の局所制御率の向上と有害事象の低減に繋がり、患者に安全な放射線治療を提供する可能性がある。また本研究成果は、4次元コーンビームCTの短時間撮像を可能とし、患者体動の誘発や腫瘍位置および動きの変化を最小限にし、結果として位置照合精度の向上に繋がる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (22 results)

All 2021 2020 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (17 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Impact of four-dimensional cone-beam computed tomography on target localization for gastric mucosa-associated lymphoid tissue lymphoma radiotherapy: reducing planning target volume2021

    • Author(s)
      Shimohigashi Y, Toya R, Saito T, Kono Y, Doi Y, Fukugawa Y, Watakabe T, Matsumoto T, Kai Y, Maruyama M, Oya N.
    • Journal Title

      Radiation Oncology

      Volume: 16 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s13014-020-01734-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Image quality evaluation of in-treatment four-dimensional cone-beam computed tomography in volumetric-modulated arc therapy for stereotactic body radiation therapy2019

    • Author(s)
      Shimohigashi, Y. Doi, Y. Kouno, Y. Yotsuji, Y. Maruyama, M. Kai, Y. Toya, R.
    • Journal Title

      Phys Med

      Volume: 68 Pages: 10-16

    • DOI

      10.1016/j.ejmp.2019.11.003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Target volume and motion position evaluation of four-dimensional cone-beam CT: comparison with 4D-CT using dynamic thorax phantom2019

    • Author(s)
      Yasuhiro Doi, Yoshinobu Shimohigashi, Yohei Yotsuji, Masato Maruyama, Yudai Kai, Ryo Toya
    • Journal Title

      Biomedical Physics & Engineering Express

      Volume: 5 Issue: 3 Pages: 035016-035016

    • DOI

      10.1088/2057-1976/ab1054

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Image quality of four-dimensional cone-beam computed tomography obtained at various gantry rotation speeds for liver stereotactic body radiation therapy with fiducial markers2018

    • Author(s)
      Shimohigashi Yoshinobu、Araki Fujio、Maruyama Masato、Yonemura Keisuke、Nakaguchi Yuji、Kai Yudai、Toya Ryo
    • Journal Title

      Physica Medica

      Volume: 45 Pages: 19-24

    • DOI

      10.1016/j.ejmp.2017.11.020

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Four-dimensional cone-beam computed tomography-guided radiotherapy for gastric lymphoma2017

    • Author(s)
      Toya Ryo、Saito Tetsuo、Shimohigashi Yoshinobu、Yotsuji Yohei、Matsuyama Tomohiko、Watakabe Takahiro、Kai Yudai、Yamashita Yasuyuki、Oya Natsuo
    • Journal Title

      Jpn J Radiol

      Volume: 36 Issue: 2 Pages: 159-163

    • DOI

      10.1007/s11604-017-0698-8

    • NAID

      210000185088

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Determination of planning target volume margin for gastric lymphoma radiotherapy using daily four-dimensional cone-beam computed tomography2020

    • Author(s)
      Yoshinobu shimohigashi, Yasuhiro Doi, Yumiko Kono, Masato Maruyama, Yudai Kai, Ryo Toya.
    • Organizer
      2020 Joint AAPM/COMP Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Validation of four-dimensional computed tomography without an external respiratory signals device for the radiotherapy planning of lung cancer patients2020

    • Author(s)
      Yoshinobu shimohigashi, Yasuhiro Doi, Yumiko Kono, Masato Maruyama, Yudai Kai, Ryo Toya.
    • Organizer
      2020 Joint AAPM/COMP Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肺の放射線治療計画におけるDevice-less 4D-CTの評価2020

    • Author(s)
      土井康寛、下東吉信、甲斐祐大、倉岡杏希子、松山倫延、幸野佑光子、丸山雅人
    • Organizer
      第13回南九州地域放射線治療技術合同研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 呼吸性移動を伴う腫瘍に対する画像誘導放射線治療2020

    • Author(s)
      下東吉信
    • Organizer
      第13回南九州地域放射線治療技術合同研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肺腫瘍の放射線治療計画におけるDevice-less 4D-CTの評価2020

    • Author(s)
      土井康寛、下東吉信、甲斐祐大、倉岡杏希子、松山倫延、幸野佑光子、丸山雅人
    • Organizer
      日本放射線技術学会第76回総会学術大会 Web開催
    • Related Report
      2019 Research-status Report
  • [Presentation] Validation of Four-Dimensional Computed Tomography Without An External Respiratory Signals Device for the Radiotherapy Planning of Lung Cancer Patients2020

    • Author(s)
      Y Shimohigashi, Y Doi, Y Kono, M Maruyama, Y Kai, R Toya
    • Organizer
      2020 joint AAPM/COMP Meeting VIRTUAL
    • Related Report
      2019 Research-status Report
  • [Presentation] Determination of Planning Target Volume Margin for Gastric Lymphoma Radiotherapy Using Daily Four-Dimensional Cone-Beam Computed Tomography2020

    • Author(s)
      Y Shimohigashi, Y Doi, Y Kono, M Maruyama, Y Kai, R Toya
    • Organizer
      2020 joint AAPM/COMP Meeting VIRTUAL
    • Related Report
      2019 Research-status Report
  • [Presentation] Image Quality of In-treatment 4D-CBCT obtained at various prescription doses in VMAT for SBRT of lung tumor: A phantom study2019

    • Author(s)
      Yoshinobu Shimohigashi, Yasuhiro Doi, Masato Maruyama, Yohei Yotsuji, Yudai Kai and Ryo Toya
    • Organizer
      ESTRO 38 conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肝腫瘍定位放射線治療におけるin-treatment 4D-CBCTの評価2019

    • Author(s)
      土井康寛、下東吉信、四辻瑶平、甲斐祐大、倉岡杏希子、松山倫延、幸野佑光子、丸山雅人、東家亮
    • Organizer
      第18回熊本県放射線技師会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 4D-CBCTを用いた胃MALTリンパ腫の放射線治療におけるPTVマージンの評価2019

    • Author(s)
      幸野佑光子、下東吉信、土井康寛、四辻瑶平、甲斐祐大、倉岡杏希子、松山倫延、折田史織、芳山史晃、丸山雅人、東家亮
    • Organizer
      第17回熊本放射線治療物理・技術研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肺定位放射線治療におけるin-treatment 4D-CBCTの評価2019

    • Author(s)
      土井康寛、下東吉信、四辻瑶平、甲斐祐大、倉岡杏希子、松山倫延、幸野佑光子、丸山雅人、東家亮
    • Organizer
      第17回熊本放射線治療物理・技術研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 4D-CBCTを用いた胃MALTリンパ腫の放射線治療におけるPTVマージンの評価2019

    • Author(s)
      幸野佑光子、下東吉信、土井康寛、四辻瑶平、甲斐祐大、倉岡杏希子、松山倫延、丸山雅人、東家亮
    • Organizer
      第14回九州放射線医療学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肝腫瘍定位放射線治療における in treatment 4D-CBCT の評価2019

    • Author(s)
      土井康寛,下東吉信,四辻瑶平,甲斐祐大,倉岡杏希子,中村祐也,松山倫延,丸山雅人
    • Organizer
      第 12 回南九州地域放射線治療技術合同研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Image Quality of In-Treatment 4D-CBCT Obtained at Various Prescription Doses in VMAT for SBRT of Lung Tumor: A Phantom Study2019

    • Author(s)
      YOSHINOBU SHIMOHIGASHI, YASUHIRO DOI, MASATO MARUYAMA, YOHEI YOTSUJI, YUDAI KAI and RYO TOYA
    • Organizer
      ESTRO 38 conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Image quality of 4D-CBCT with varying gantry rotation speeds for liver SBRT with fiducial markers2017

    • Author(s)
      Shimohigashi Yoshinobu、Araki Fujio、Maruyama Masato、Yonemura Keisuke、Nakaguchi Yuji、Kai Yudai、Toya Ryo
    • Organizer
      第59回米国医学物理学会学術大会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 4D-CBCTを用いた胃MALTリンパ腫に対する放射線治療の一例2017

    • Author(s)
      四辻瑶平,下東吉信,米村圭祐,松山倫延,中村祐也,倉岡杏希子,甲斐祐大,中口裕二,丸山雅人,東家亮
    • Organizer
      第15回熊本県放射線治療物理・技術研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肝臓SBRTにおけるガントリー回転速度の違いによる4D-CBCTの画質評価2017

    • Author(s)
      米村圭祐,下東吉信,東家亮,丸山雅人,中口裕二,甲斐祐大,倉岡杏希子,松山倫延,中村祐也,大屋夏生
    • Organizer
      第30回日本放射線腫瘍学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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