| Project/Area Number |
17K16478
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
Oura Kazumasa 岩手医科大学, 医学部, 助教 (20611015)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 造影超音波検査 / 超音波造影剤 / STIC / 頚動脈 / 頸動脈プラーク / プラーク内新生血管 / 頸動脈超音波 |
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| Outline of Final Research Achievements |
The presence of intraplaque neovascularization has been identified as a factor in unstable carotid plaque. Contrast-enhanced ultrasonography (US) has been used to evaluate such neovascularization. The spatio-temporal image correlation (STIC) method is an approach developed for displaying fetal cardiac images on multiplanar displays. We have examined contrast media flowing within plaque three-dimensionally using the STIC method and assessed with gray-scale median. We evaluated whether the STIC method was superior to conventional contrast-enhanced US with time intensity curve in evaluating neovascularization, using a pathological specimen provided from carotid endarterectomy. Both of the STIC method and conventional contrast-enhanced US correlated with the area of neovascularization in the plaque. However, there were no significant difference between STIC method and conventional contrast-enhanced US.
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| Academic Significance and Societal Importance of the Research Achievements |
STIC法による頚動脈プラーク新生血管の評価法を確立することにより、従来の2D造影超音波検査よりも正確にプラーク内の新生血管を観察可能となり、より正確な脳梗塞発症リスクの評価が可能になると考えたが、今回の研究ではSTIC方の優位性は証明できなかった。
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