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Contrast-enhanced ultrasonography using the spatio-temporal image correlation (STIC) method for the evaluation of intraplaque neovascularization in carotid artery plaque

Research Project

Project/Area Number 17K16478
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionIwate Medical University

Principal Investigator

Oura Kazumasa  岩手医科大学, 医学部, 助教 (20611015)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords造影超音波検査 / 超音波造影剤 / STIC / 頚動脈 / 頸動脈プラーク / プラーク内新生血管 / 頸動脈超音波
Outline of Final Research Achievements

The presence of intraplaque neovascularization has been identified as a factor in unstable carotid plaque. Contrast-enhanced ultrasonography (US) has been used to evaluate such neovascularization. The spatio-temporal image correlation (STIC) method is an approach developed for displaying fetal cardiac images on multiplanar displays. We have examined contrast media flowing within plaque three-dimensionally using the STIC method and assessed with gray-scale median. We evaluated whether the STIC method was superior to conventional contrast-enhanced US with time intensity curve in evaluating neovascularization, using a pathological specimen provided from carotid endarterectomy. Both of the STIC method and conventional contrast-enhanced US correlated with the area of neovascularization in the plaque. However, there were no significant difference between STIC method and conventional contrast-enhanced US.

Academic Significance and Societal Importance of the Research Achievements

STIC法による頚動脈プラーク新生血管の評価法を確立することにより、従来の2D造影超音波検査よりも正確にプラーク内の新生血管を観察可能となり、より正確な脳梗塞発症リスクの評価が可能になると考えたが、今回の研究ではSTIC方の優位性は証明できなかった。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] 頸動脈超音波検査の最新技術と今後の課題2018

    • Author(s)
      大浦一雅、大庭英樹、寺山靖夫
    • Journal Title

      臨床検査

      Volume: 2 Pages: 144-149

    • Related Report
      2017 Research-status Report
  • [Journal Article] spatio-temporal image correlation(STIC)法を用いた造影頸動脈超音波検査によるプラーク内新生血管の評価2017

    • Author(s)
      加藤正義、大浦一雅、大庭英樹、小林正和、小笠原邦昭、人見次郎、寺山靖夫
    • Journal Title

      岩手医学雑誌

      Volume: 69 Pages: 255-264

    • NAID

      40021420301

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of Three-Dimensional T1-Weighted Magnetic Resonance and Contrast-Enhanced Ultrasound Plaque Images for Severe Stenosis of the Cervical Carotid Artery2017

    • Author(s)
      Shimada Yasuyoshi、Oikawa Kohki、Fujiwara Shunrou、Ogasawara Yasushi、Sato Yuiko、Narumi Shinsuke、Kato Tadayoshi、Oura Kazumasa、Terayama Yasuo、Sasaki Makoto、Fujimoto Kentaro、Yoshida Jun、Ogasawara Kuniaki
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 26 Issue: 9 Pages: 1916-1922

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.06.029

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative cervical carotid artery contrast-enhanced ultrasound findings are associated with development of microembolic signals on transcranial Doppler during carotid exposure in endarterectomy.2017

    • Author(s)
      Oikawa K, Kato T, Oura K, Narumi S, Sasaki M, Fujiwara S, Kobayashi M, Matsumoto Y, Nomura JI, Yoshida K, Terayama Y, Ogasawara K.
    • Journal Title

      Atherosclerosis

      Volume: 260 Pages: 87-93

    • DOI

      10.1016/j.atherosclerosis.2017.03.026

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant

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Published: 2017-04-28   Modified: 2020-03-30  

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