| Project/Area Number |
17K16485
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 放射線治療 / 照射位置誤差 / 線量の不確かさ / 治療計画の頑健性 / 評価ツール / 放射線治療計画 / セットアップエラー / 線量不確かさ / 線量分布 / ロバスト性 / 不確かさ / 多項カオス展開 |
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| Outline of Final Research Achievements |
Advanced radiotherapy techniques are more sensitive to treatment delivery uncertainties such as patient setup uncertainties and organ motion that might lead to treatment target underdose and organ at risk overdose. Therefore the evaluation of treatment plan robustness against the uncertainties is critically considered to be an important factor contributing to sufficient dose coverage to the target and meet the clinical requirement for normal organs. The need for plan robustness quantification has been recognized but not implemented in routine clinical practice due to high computational cost.
This study aimed to develop the in-house stand-alone tool which can quantify the plan robustness under an arbitrary error scenario and establish site-specific robustness database, and investigate the feasibility for intensity modulated radiotherapy (IMRT) plans of prostate and head and neck cancers.
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| Academic Significance and Societal Importance of the Research Achievements |
安全で精度の高い放射線治療を行っていく上では、施設ごと、治療部位ごとに予期される不確かさに対する治療計画の頑健性の許容値を決定することが重要である。
本研究で開発したツールにより、任意の不確かさにおける治療計画の頑健性を評価することが出来る。またデータを収集し、データベース化することで、将来的に頑健性の高い治療計画の作成方法の開発や治療方針決定に繋がることが期待される。
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