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Development of a new non-adhensive microballoon catheter for n-butyl-2-cyanoacrylate (NBCA) embolization

Research Project

Project/Area Number 17K16487
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionTokai University

Principal Investigator

HAYASHI Toshihiko  東海大学, 医学部, 助教 (50780186)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血管内治療 / マイクロバルーンカテーテル / 永久液状塞栓物質 / NBCA / プラズマ技術 / フッ素添加ダイヤモンド系ナノ薄膜 / リピオドール
Outline of Final Research Achievements

The aim of this study was to develop a new non-adhensive microballoon catheter coated fluorinated diamond-like carbon (F-DLC) for n-butyl-2-cyanoacrylate (NBCA) embolization. We optimized the deposition conditions. In vitro study, thin F-DLC films demonstrated lower adhesion to NBCA than polyurethane (PU) substrates. Although the target value was not reached, a difference in tensile pressure was observed between the conventional microballoon catheter and the new microballoon catheter, suggesting a decrease in adhesion.

Academic Significance and Societal Importance of the Research Achievements

血管内治療で用いられる液状永久塞栓物質の一つであるn-butyl-2-cyanoacrylate (NBCA) は強力な止血効果が得られる一方で,NBCA注入時直ちにカテーテルを抜去しなければならないことや塞栓範囲が一定しないなどの理由から術者に熟練した技術が求められる.NBCAに固着しないマイクロバルーンカテーテルが開発されることで塞栓範囲のコントロールを容易にし,カテーテルの血管内での固着に起因する医原性合併症を予防し得る.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] A Stepwise Embolization Strategy for a Bronchial Arterial Aneurysm: Proximal Coil and Distal Glue with the Optional use of a Microballoon Occlusion system.2018

    • Author(s)
      Mine T, Matsumoto T, Hayashi T, Tomita K, Masuda K, Kawashima M, Sakamaki F, Hasebe T.
    • Journal Title

      Cardiovasc Intervent Radiol

      Volume: 41 Pages: 1267-1273

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Right Aortic Arch with Mirror-image Branching in Adults: Evaluation Using CT.2018

    • Author(s)
      Hayashi T, Ichikawa T, Yamamuro H, Ono S, Kobayashi M, Nomura T, Hashida K, Yashiro H, Okochi T, Koizumi J, Shimura S, Hasebe T, Imai Y.
    • Journal Title

      Tokai J Exp Clin Med

      Volume: 43 Pages: 30-37

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microballoon-related interventions in various endovascular treatments of body trunk lesions.2018

    • Author(s)
      Matsumoto T, Tomita K, Suda S, Hashida K, Maegawa S, Hayashi T, Yamagami T, Suzuki T, Hasebe T.
    • Journal Title

      Minim Invasive Ther Allied Technol.

      Volume: 27 Issue: 1 Pages: 2-10

    • DOI

      10.1080/13645706.2017.1398174

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 門脈肺静脈吻合を伴った胃静脈瘤に対し,バルーン閉塞下逆行性経静脈塞栓を施行した1例2017

    • Author(s)
      林 敏彦, 松本 知博, 須田 慧, 富田 康介, 嶺 貴彦, 橋田 和靖, 長谷部 光泉, 永田 順子, 高清水 眞二, 小島 清一郎, 市川 仁志, 白井 孝之, 渡辺 勲史
    • Journal Title

      門脈圧亢進症学会雑誌

      Volume: 23 Pages: 191-196

    • NAID

      130007784408

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility and Safety of Repeated Transarterial Chemoembolization Using Miriplatin-Lipiodol Suspension for Hepatocellular Carcinoma.2017

    • Author(s)
      Matsumoto T, Ichikawa H, Imai J, Hayashi T, Tomita K, Mine T, Kojima S, Watanabe N, Hasebe T.
    • Journal Title

      Anticancer Research

      Volume: 37 Issue: 6 Pages: 3183-3187

    • DOI

      10.21873/anticanres.11678

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biocompatibility Tests and Adhesion Improvements for Hydrogen-Free Amorphous Carbon for Blood-Contacting Medical Devices2017

    • Author(s)
      Y. Yamato, S. Maegawa, T. Hasebe, K. Bito, T. Matsumoto, T. Mine, T. Hayashi, A. Hotta, T. Suzuki.
    • Journal Title

      Sensors and Materials

      Volume: 29 Pages: 843

    • DOI

      10.18494/SAM.2017.1573

    • ISSN
      0914-4935, 2435-0869
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 上腸間膜動脈起始の変異脾動脈瘤に対して、複合balloon assist下のcoil塞栓術を施行した1例2017

    • Author(s)
      須田 慧, 嶺 貴彦, 松本 知博, 林 敏彦, 橋田 和靖, 富田 康介, 及川 惠子, 小林 義典, 長谷部 光泉
    • Organizer
      第46回日本IVR学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腹腔動脈合併尾側膵切除術前の膵アーケード経由総肝動脈遠位マイクロバルーン閉塞下総肝動脈コイル塞栓術2017

    • Author(s)
      富田 康介, 松本 知博, 嶺 貴彦, 林 敏彦, 橋田 和靖, 須田 慧, 宇田 周司, 和泉 秀樹, 幕内 博康, 長谷部 光泉
    • Organizer
      第46回日本IVR学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] リンパ系インターベンション:臨床におけるリンパ造影・胸管塞栓術と動物モデル確立への試み2017

    • Author(s)
      松本 知博, 富田 康介, 須田 慧, 林 敏彦, 橋田 和靖, 嶺 貴彦, 吉松 梨香, 山上 卓士, 長谷部 光泉
    • Organizer
      第23回日本血管内治療学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Feasibility and safety of repeated transarterial chemoembolization using miriplatin-lipiodol suspension for unresectable hepatocellular carcinoma2017

    • Author(s)
      Matsumoto T, Ichikawa H, Mine T, Hayashi T, Tomita K, Suda S, Hasebe T
    • Organizer
      CIRSE2017
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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