| Project/Area Number |
17K16487
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血管内治療 / マイクロバルーンカテーテル / 永久液状塞栓物質 / NBCA / プラズマ技術 / フッ素添加ダイヤモンド系ナノ薄膜 / リピオドール |
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| Outline of Final Research Achievements |
The aim of this study was to develop a new non-adhensive microballoon catheter coated fluorinated diamond-like carbon (F-DLC) for n-butyl-2-cyanoacrylate (NBCA) embolization. We optimized the deposition conditions. In vitro study, thin F-DLC films demonstrated lower adhesion to NBCA than polyurethane (PU) substrates. Although the target value was not reached, a difference in tensile pressure was observed between the conventional microballoon catheter and the new microballoon catheter, suggesting a decrease in adhesion.
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| Academic Significance and Societal Importance of the Research Achievements |
血管内治療で用いられる液状永久塞栓物質の一つであるn-butyl-2-cyanoacrylate (NBCA) は強力な止血効果が得られる一方で，NBCA注入時直ちにカテーテルを抜去しなければならないことや塞栓範囲が一定しないなどの理由から術者に熟練した技術が求められる．NBCAに固着しないマイクロバルーンカテーテルが開発されることで塞栓範囲のコントロールを容易にし，カテーテルの血管内での固着に起因する医原性合併症を予防し得る．
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