Development of a new non-adhensive microballoon catheter for n-butyl-2-cyanoacrylate (NBCA) embolization

• Project/Area Number: 17K16487
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tokai University
• Principal Investigator: HAYASHI Toshihiko 東海大学, 医学部, 助教 (50780186)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 血管内治療 / マイクロバルーンカテーテル / 永久液状塞栓物質 / NBCA / プラズマ技術 / フッ素添加ダイヤモンド系ナノ薄膜 / リピオドール

Outline of Final Research Achievements

The aim of this study was to develop a new non-adhensive microballoon catheter coated fluorinated diamond-like carbon (F-DLC) for n-butyl-2-cyanoacrylate (NBCA) embolization. We optimized the deposition conditions. In vitro study, thin F-DLC films demonstrated lower adhesion to NBCA than polyurethane (PU) substrates. Although the target value was not reached, a difference in tensile pressure was observed between the conventional microballoon catheter and the new microballoon catheter, suggesting a decrease in adhesion.

Academic Significance and Societal Importance of the Research Achievements

血管内治療で用いられる液状永久塞栓物質の一つであるn-butyl-2-cyanoacrylate (NBCA) は強力な止血効果が得られる一方で，NBCA注入時直ちにカテーテルを抜去しなければならないことや塞栓範囲が一定しないなどの理由から術者に熟練した技術が求められる．NBCAに固着しないマイクロバルーンカテーテルが開発されることで塞栓範囲のコントロールを容易にし，カテーテルの血管内での固着に起因する医原性合併症を予防し得る．

Research Products

• [Journal Article] A Stepwise Embolization Strategy for a Bronchial Arterial Aneurysm: Proximal Coil and Distal Glue with the Optional use of a Microballoon Occlusion system. (2018)
  • Author(s): Mine T, Matsumoto T, Hayashi T, Tomita K, Masuda K, Kawashima M, Sakamaki F, Hasebe T.
  • Journal Title: Cardiovasc Intervent Radiol Volume: 41 Pages: 1267-1273
  • Peer Reviewed
• [Journal Article] Right Aortic Arch with Mirror-image Branching in Adults: Evaluation Using CT. (2018)
  • Author(s): Hayashi T, Ichikawa T, Yamamuro H, Ono S, Kobayashi M, Nomura T, Hashida K, Yashiro H, Okochi T, Koizumi J, Shimura S, Hasebe T, Imai Y.
  • Journal Title: Tokai J Exp Clin Med Volume: 43 Pages: 30-37
  • Peer Reviewed / Open Access
• [Journal Article] Microballoon-related interventions in various endovascular treatments of body trunk lesions. (2018)
  • Author(s): Matsumoto T, Tomita K, Suda S, Hashida K, Maegawa S, Hayashi T, Yamagami T, Suzuki T, Hasebe T.
  • Journal Title: Minim Invasive Ther Allied Technol. Volume: 27 Issue: 1 Pages: 2-10
  • DOI: 10.1080/13645706.2017.1398174
  • Peer Reviewed
• [Journal Article] 門脈肺静脈吻合を伴った胃静脈瘤に対し，バルーン閉塞下逆行性経静脈塞栓を施行した1例 (2017)
  • Author(s): 林 敏彦, 松本 知博, 須田 慧, 富田 康介, 嶺 貴彦, 橋田 和靖, 長谷部 光泉, 永田 順子, 高清水 眞二, 小島 清一郎, 市川 仁志, 白井 孝之, 渡辺 勲史
  • Journal Title: 門脈圧亢進症学会雑誌 Volume: 23 Pages: 191-196
  • NAID: 130007784408
  • Peer Reviewed
• [Journal Article] Feasibility and Safety of Repeated Transarterial Chemoembolization Using Miriplatin-Lipiodol Suspension for Hepatocellular Carcinoma. (2017)
  • Author(s): Matsumoto T, Ichikawa H, Imai J, Hayashi T, Tomita K, Mine T, Kojima S, Watanabe N, Hasebe T.
  • Journal Title: Anticancer Research Volume: 37 Issue: 6 Pages: 3183-3187
  • DOI: 10.21873/anticanres.11678
  • Peer Reviewed
• [Journal Article] Biocompatibility Tests and Adhesion Improvements for Hydrogen-Free Amorphous Carbon for Blood-Contacting Medical Devices (2017)
  • Author(s): Y. Yamato, S. Maegawa, T. Hasebe, K. Bito, T. Matsumoto, T. Mine, T. Hayashi, A. Hotta, T. Suzuki.
  • Journal Title: Sensors and Materials Volume: 29 Pages: 843
  • DOI: 10.18494/SAM.2017.1573
  • ISSN: 0914-4935, 2435-0869
  • Peer Reviewed
• [Presentation] 上腸間膜動脈起始の変異脾動脈瘤に対して、複合balloon assist下のcoil塞栓術を施行した1例 (2017)
  • Author(s): 須田 慧, 嶺 貴彦, 松本 知博, 林 敏彦, 橋田 和靖, 富田 康介, 及川 惠子, 小林 義典, 長谷部 光泉
  • Organizer: 第46回日本IVR学会総会
• [Presentation] 腹腔動脈合併尾側膵切除術前の膵アーケード経由総肝動脈遠位マイクロバルーン閉塞下総肝動脈コイル塞栓術 (2017)
  • Author(s): 富田 康介, 松本 知博, 嶺 貴彦, 林 敏彦, 橋田 和靖, 須田 慧, 宇田 周司, 和泉 秀樹, 幕内 博康, 長谷部 光泉
  • Organizer: 第46回日本IVR学会総会
• [Presentation] リンパ系インターベンション：臨床におけるリンパ造影・胸管塞栓術と動物モデル確立への試み (2017)
  • Author(s): 松本 知博, 富田 康介, 須田 慧, 林 敏彦, 橋田 和靖, 嶺 貴彦, 吉松 梨香, 山上 卓士, 長谷部 光泉
  • Organizer: 第23回日本血管内治療学会総会
• [Presentation] Feasibility and safety of repeated transarterial chemoembolization using miriplatin-lipiodol suspension for unresectable hepatocellular carcinoma (2017)
  • Author(s): Matsumoto T, Ichikawa H, Mine T, Hayashi T, Tomita K, Suda S, Hasebe T
  • Organizer: CIRSE2017