| Project/Area Number |
17K16551
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 食道扁平上皮癌 / 治療抵抗性 / マイトファジー / 低酸素 / ミトコンドリア / 食道癌 |
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| Outline of Final Research Achievements |
We researched esophageal squamous cell carcinoma (ESCC), which is frequently diagnosed in Eastern Asia. We focused on hypoxia and autophagy. Hypoxia is known as cancer related microenvironment. Autophagy is a self-degradative process and become popular after Dr. Osumi won the Novel Prize in 2016 with clarifying the mechanism of autophagy. We collected 159 ESCC samples from patients who had surgically resection at Osaka University Hospital and investigated the expressions of factors related to hypoxia and autophagy. We also investigated the expressions in ESCC cell lines with or without hypoxic condition. The result suggested that hypoxia promotes selective autophagy to mitochondria, which is strongly related with apoptosis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、食道扁平上皮癌においては低酸素環境でのミトコンドリア選択的オートファジーが誘導されている可能性が示唆された。今後、低酸素環境を阻害する薬剤やミトコンドリア選択的オートファジーを阻害する薬剤の開発がすすめば、食道癌患者の予後を改善させることにつながると考えられる。また、低酸素環境はあらゆる他の癌種にも共通するものであることから、他癌種の治療開発においても同様に有用なエビデンスであり、全てのがんの死亡率の減少に大きく貢献することができる。
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