| Project/Area Number |
17K16553
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
TANAKA TOMOKO 神戸大学, 医学部附属病院, 医師 (10755630)
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| Research Collaborator |
OKA Yuma
YANAGIDA Masatoshi
SUGITA Yutaka
FUKUOKA Eiji
ARIMOTO Akira
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | イメージングサイトメトリー / CD8+T細胞 / 抗腫瘍免疫応答 / 免疫応答 / 疲弊状態 / 腫瘍特異的T細胞 / 抗腫瘍免疫 / 免疫疲弊 / T細胞受容体 |
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| Outline of Final Research Achievements |
In antitumor immunity, T cells play a central role to eliminate cancer cells. T cells exhaust by chronic antigen-stimulation in cancer patients. The function of exhausted T cells decrease and can’t remove cancer specific antigen. At present, functional evaluation of T cells takes several days to obtain results. It is important to establish a system that can quickly assess the functional depression and exhaustion of T cells. Therefore, in this research project, we propose new method which detect IS formation of ex vivo T cells by using imaging cytometry. The study was conducted using T cells in human peripheral blood.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究計画は今年度で終了するが、引き続き検討を続ける計画である。MC様形成は抗腫瘍免疫応答の中心であるT細胞の機能を示すことが想定され、癌治療への応用が期待される。
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