| Project/Area Number |
17K16569
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 食道狭窄 / 再生医療 / 高度炎症 / il10 / 遺伝子導入 / 細胞培養 / 上皮細胞 / 再生医学 / 細胞・組織 |
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| Outline of Final Research Achievements |
There were several treatments by cell therapies uisng tissue-enginnering. However, the effectiveness of the cell therapies was limited in the severe inflammatory condition . Thus, it is necessary to develop the novel cell therapy for the severe inflammatory condition.In this study, anti-innflammatory cytokine help to keep the normal conditon after injury. The specific gene transfer was tried in the several experiments. The gene-editing technique gave the influence about viability and growth of epithelial cells. Nowaday, we have develop the novel gene editing protocol.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでの治療学は病巣を切除するのみであり、治癒に関しては、生体の反応に委ねていた。そのため、一定の確立で合併症が発症してしまう。細胞治療、再生医療は治癒を促進できる治療法として注目されている。本研究により、抗炎症性因子が創傷治癒に与える影響が示唆された。低侵襲治療の基盤となる理論が確認できたため、創薬の基盤となるだけでなく、細胞治療として新たな医療となる可能性が示唆された。
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