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Evaluation of severity and reversibility of chronic right heart failure by epigenetic gene regulation

Research Project

Project/Area Number 17K16588
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Research InstitutionNiigata University

Principal Investigator

Sugimoto Ai  新潟大学, 医歯学総合病院, 助教 (00723941)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsエピジェネティック修飾 / 右室心筋 / 先天性心疾患 / スプライスファクター / SF3B1 / 免疫組織染色 / 右室心筋病理 / 右室心筋病理所見 / 右室心筋病理組織検査 / 慢性右心不全 / 心筋病理
Outline of Final Research Achievements

Patients with congenital heart disease who underwent scheduled intra-cardiac procedure with right ventricular muscle resection during this study period were included. Immunostaining was performed, and histoscore (H-score) was calculated as perviously reported. A total number of patients was 52, composed of various ages. A half of them were diagnosed with tetralogy of Fallot; the rest of them had various diagnosis. H-score was 164 ± 44. H-scores and preoperative data were compared. Because of the small number of the patients with various backgrounds, it was difficult to detect specific preoperative hemodynamic factors related to H-scores. At least, very long diseased interval significantly related to low H-scores.

Academic Significance and Societal Importance of the Research Achievements

先天性心疾患では、近年の周術期管理および外科治療の進歩により、大多数の疾患で成人に到達するようになり、術後遠隔期の残存病変・続発症や、慢性心不全、再治療介入のタイミングや内容が、新たな重要な分野となっている。
本研究成果が、この再治療介入を要する患者における、心機能の維持を念頭においた手術のタイミングを推定する新たな指標の模索につながり、最終的に、これら疾患群の予後改善に寄与することが、本研究の本質的な目的である。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2020

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Adverse impact of univentricular pacing for the patient with functional single ventricle: successful conversion to cardiac resynchronization therapy2020

    • Author(s)
      Ai Sugimoto, Kiyohiro Takigiku, Shuichi Shiraishi, Masashi Takahashi, Masanori Tsuchida
    • Journal Title

      Surgical Case Reports

      Volume: 13 Issue: 1 Pages: 101-101

    • DOI

      10.1186/s40792-020-00863-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 小児胸骨正中切開後縦隔炎に対する治療戦略:洗浄ドレナージ+一期的胸骨閉鎖2020

    • Author(s)
      杉本愛、白石修一、高橋昌、土田正則
    • Organizer
      第50回日本心臓血管外科学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mid-term outcome after coronary artery bypass grafting for children2020

    • Author(s)
      杉本愛、白石修一、高橋昌、土田正則
    • Organizer
      第73回日本胸部外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 二心室治療を目指した経過中、左上大静脈の経路変更を要した両側上大静脈を有する2症例2020

    • Author(s)
      杉本愛、白石修一、高橋昌、土田正則
    • Organizer
      第56回日本小児循環器学会総会・学術集会
    • Related Report
      2020 Annual Research Report

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Published: 2017-04-28   Modified: 2025-11-20  

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