Development of angiogenesis therapy by microRNA expressed in mice with angiogenic ability

• Project/Area Number: 17K16593
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Yamaguchi University
• Principal Investigator: UENO Koji 山口大学, 医学部附属病院, 助教 (30736070)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: microRNA / 血管新生 / エクソソーム / 細胞外microRNA

Outline of Final Research Achievements

MicroRNAs involved into exosome from mice with angiogenic ability might have high angiogenic ability from comparative analysis of microRNAs based on difference of angiogenic ability in mice.

Academic Significance and Societal Importance of the Research Achievements

本研究において、血管新生能が高いマウスのエクソソームに内包されている複数のmicroRNAは、血管新生能が低いマウスを用いた下肢虚血モデルの血流を改善したことから、microRNAは核酸医薬としての可能性があることを示唆した結果である。