Investigation of mechanism for radiation induced brain tumor stem cell migration

• Project/Area Number: 17K16668
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: National Institute of Advanced Industrial Science and Technology (2019); University of Tsukuba (2017-2018)
• Principal Investigator: Sun Lue 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (40757704)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 放射線治療 / 脳腫瘍幹細胞 / 転移 / 浸潤 / 放射線 / 脳腫瘍 / がん幹細胞 / 代謝 / ミトコンドリア / レドックス

Outline of Final Research Achievements

We investigated mechanism for radiation induced brain tumor stem cell migration using we established brain tumor stem like cell line.

Academic Significance and Societal Importance of the Research Achievements

本研究は、放射線照射後の細胞の遊走浸潤という独自の視点から、脳腫瘍幹細胞様細胞の新たな放射線抵抗性メカニズムを解明しようと試みるものである。研究の成果は、遊走阻止効果を期待した薬剤併用療法に関して、理論的根拠を導くことができる。

Research Products

• [Journal Article] Abscopal Effect Induced by a Combined Treatment with Anti-PD-1 Antibody and BM-DCs after X-ray in a Melanoma Mouse Model (2018)
  • Author(s): Yuzi Wang, Lue Sun, Xiaokang Li, Koji Tsuboi
  • Journal Title: CANCER SCIENCE Volume: 109 Pages: 117-117
  • Peer Reviewed / Open Access
• [Journal Article] Energy and ROS metabolism in radioresistant brain tumor cells (2018)
  • Author(s): Sun Lue、Yuzi Wang、Masaoki Kohzaki、Tsuboi Koji
  • Journal Title: CANCER SCIENCE Volume: 109 Pages: 267-267
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets (2017)
  • Author(s): Sun Lue、Moritake Takashi、Ito Kazuya、Matsumoto Yoshitaka、Yasui Hironobu、Nakagawa Hidehiko、Hirayama Aki、Inanami Osamu、Tsuboi Koji
  • Journal Title: PLOS ONE Volume: 12 Issue: 4 Pages: 1-24
  • DOI: 10.1371/journal.pone.0176162
  • Peer Reviewed / Open Access
• [Journal Article] A combined local treatment with anti-PD-1 antibody and bone marrow derived dendritic cells after x-ray irradiation to subcutaneous melanoma in a murine model. (2017)
  • Author(s): Yuzi Wang, Lue Sun, Xiaokang Li, Koji Tsuboi
  • Journal Title: Journal of Clinical Oncology Volume: 35 Issue: 15_suppl Pages: e14541-e14541
  • DOI: 10.1200/jco.2017.35.15_suppl.e14541
  • Peer Reviewed / Open Access
• [Presentation] A Combined Local Treatment with Anti-PD-1 Antibody and Bone Marrow Derived Dendritic Cells after X-ray Irradiation to Subcutaneous Melanoma in a Murine Model. (2017)
  • Author(s): Yuzi Wang, Lue Sun, Xiaokang Li and Koji Tsuboi.
  • Organizer: The 2017 ASCO Annual Meeting
  • Int'l Joint Research
• [Presentation] Energy and ROS metabolism in radioresistant brain tumor cells. (2017)
  • Author(s): Lue Sun, Takashi Moritake, Yoshitaka Matsumoto, Yuzi Wang, Masaoki Kohzaki, Akira Ootsuyama, Ryuji Okazaki and Koji Tsuboi.
  • Organizer: 第76回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] Abscopal Effect Induced by a Combined Treatment with Anti-PD-1 Antibody and BM-DCs after X-ray in a Melanoma Mouse Model (2017)
  • Author(s): Yuzi Wang, Lue Sun, Xiaokang Li, Koji Tsuboi
  • Organizer: 第76回日本癌学会学術総会