Preclinical study of boron neutron capture therapy for bone metastasis
Project/Area Number |
17K16708
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Kobe Gakuin University |
Principal Investigator |
Andoh Tooru 神戸学院大学, 薬学部, 助手 (50639226)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | ホウ素中性子捕捉療法 / p-borono-L-phenylalanine / 骨転移 / 前臨床研究 / 乳癌 / 肺癌 / LAT1 / p-borono-L-phenylalanin / 癌 / 薬剤 |
Outline of Final Research Achievements |
Bone metastasis has a major impact on the quality of life that general therapy cannot control. We established a bone metastasis model with human breast cancer and lung cancer cell lines and investigated the therapeutic effect of boron neutron capture therapy (BNCT). BNCT suppressed tumor growth in cases of intramedullary small tumors without damaging normal tissues, providing preliminary evidence that it is a potentially new therapeutic option for controlling tumor growth from bone metastasis. Further research is warranted for its clinical application.
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Academic Significance and Societal Importance of the Research Achievements |
骨破壊に基づく疼痛管理を含めた骨転移の治療方法は確立された方法があるものの効果が乏しい場合において,治療やQOLの維持に難渋する場合もある. 本研究では,BNCTが骨転移の腫瘍成長とそれに伴う骨破壊を抑制することを明らかとしたため,主に骨破壊を抑制することによる疼痛管理にも応用できる可能性を示したといえる.特に一般的な放射線治療による疼痛抑制を終えた患者や骨破壊に対する治療である髄腔内への髄内釘手術を受ける患者に対して,BNCTを応用することでさらなる疼痛緩和や手術の回避ができる可能性を持つ.これらのように骨転移患者に対して新たな治療法を提供しうることを示した点に本研究の意義がある.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] Study on application of BNCT to synovial sarcoma2018
Author(s)
T. Fujimoto, M. Suzuki, S. Kuratsu, T. Sudo, T. Sakuma, Y. Sakurai, T. Takata, Y. Tamari, H. Tanaka, S. Masunaga, Y. Kinashi, N. Kondo, H. Igaki, I. Fujita , T. Andoh, M. Morishita, S. Yahiro, R. Shigemoto, T. Kawamoto, T. Akisue, H. Ichikawa, R. Kuroda, T. Hirose
Organizer
18th International Congress on Neutron Capture Therapy
Related Report
Int'l Joint Research
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[Presentation] L-type Amino Acid Transporter1 (LAT1) Expression in Clear Cell Sarcoma2017
Author(s)
T. Fujimoto, T. Sudo, T. Andoh, Y. Irino, T. Sakuma, H. Moritake, I. Fujita, T. Kawamoto, T. Akisue, T. Usui, J. Kobayashi, H. Ichikawa, R. Kuroda, M. Suzuki, T. Hirose
Organizer
The 19th International Society of Limb Salvage General Meeting
Related Report
Int'l Joint Research
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[Presentation] Evaluation of Boron Neutron Capture Therapy for Leiomyosarcoma2017
Author(s)
T. Fujimoto, N. Kamitani, T. Sudo, T. Sakuma, T. Aihara, M. Uno, Y. Kinashi, Y. Sakurai, H. Tanaka, S. Masunaga, A. Maruhashi, N. Kondo, I. Fujita, T. Andoh, T. Kawamoto, T. Akisue, H. Ichikawa, J. Hiratsuka, K. Ono, R. Kuroda, M. Suzuki, T. Hirose
Organizer
9th Young Researchers’ Boron Neutron Capture Therapy Meeting
Related Report
Int'l Joint Research
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[Presentation] L-TYPE AMINO ACID TRANSPORTER 1 (LAT1) EXPRESSES IN CLEAR CELL SARCOMA AND ITS INHIBITOR BLOCKS INCORPORATION OF ESSENTIAL AMINO ACIDS2017
Author(s)
T. Fujimoto, T. Sudo, T. Andoh, Y. Irino, T. Sakuma, H. Moritake, I. Fujita T. Kawamoto, T. Akisue, U. Takeo, J. Kobayashi, H. Ichikawa, R. Kuroda, M. Suzuki, T. Hirose
Organizer
2017 CTOS Annual Meeting
Related Report
Int'l Joint Research
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