| Project/Area Number |
17K16717
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
Sato Izumi 旭川医科大学, 大学病院, 医員 (70624196)
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| Research Collaborator |
KANDA Megumi
KANDA hirotsugu
ONODERA yoshiko
ANNO eri
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 神経障害性疼痛 / 漢方治療 / 漢方薬 / 抗癌剤 / 遺伝子治療 |
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| Outline of Final Research Achievements |
We studied the effect of Go-sha-jinki-Gan (GJG) on HIV-induced allodynia using a rat model of HIV-related neuropathic pain. Neuropathic pain was induced by the application of recombinant HIV-1 envelope protein gp120 into the sciatic nerve. Mechanical threshold was tested using the von Frey filaments. Rats were randomly assigned to one of the following four groups: gp120 group, GJG-treated gp120 group, Sham group, and GJG-treated Sham group. The GJG-treated gp120 group showed improvement of allodynia as compared to the gp120 group.
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| Academic Significance and Societal Importance of the Research Achievements |
我々のデータは、HIV関連神経障害性疼痛ラットモデルにおいて牛車腎気丸がHIV誘発性アロディニアを抑制することを示した。これにより牛車腎気丸がHIV関連神経障害性疼痛に有効である可能性が示唆された。現在、HIV関連神経障害性疼痛に対して牛車腎気丸が作用する機序について、分子生物学的検討を行っている。
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