Effects of anesthetic agents on oxytocin induced contractions of the pregnant rat myometrium in vivo and in vitro

• Project/Area Number: 17K16744
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Sapporo Medical University
• Principal Investigator: Kimizuka Motonobu 札幌医科大学, 医学部, 助教 (30758686)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 子宮筋収縮 / デクスメデトミジン / 帝王切開 / 麻酔薬 / 麻酔科学

Outline of Final Research Achievements

This study demonstrated that dexmedetomidine enhances oxytocin-induced contractions of pregnant rat myometrium more than propofol and sevoflurane. Inhibition of myofilament calcium sensitivity may have caused the inhibition of myometrial contraction by sevoflurane. Arachidonic acid may play an important role in the enhancement of myometrial contraction induced by dexmedetomidine through enhancing myofilament calcium sensitivity. Dexmedetomidine would be an advantageous anaesthetic agent during caesarean sections.

Academic Significance and Societal Importance of the Research Achievements

帝王切開中に使用する麻酔薬には子宮筋収縮を抑制する効果があり、弛緩出血などの原因とされてきた。しかし、今回の研究成果をもとに今後はデクスメデトミジンを帝王切開中の鎮静薬として使用することにより、今後弛緩出血を減らし、妊産婦死亡症例を減らすことができる可能性が示唆された。

Research Products

• [Presentation] Mechanisms and influence of anaesthetic agents on contractions of the pregnant rat myometrium in vivo. (2019)
  • Author(s): Motonobu Kimizuka
  • Organizer: Euroanaesthesia. The European Anaesthesiology Congress 2019.
  • Int'l Joint Research
• [Presentation] Mechanisms and influence of anaesthetic agents on contractions of the pregnant rat myometrium in vivo (2019)
  • Author(s): Kimizuka M.
  • Organizer: European Society of Anesthesiology
  • Int'l Joint Research
• [Presentation] Influence of anaesthetic agents on contractions of the pregnant rat myometrium in vivo. (2018)
  • Author(s): 君塚基修
  • Organizer: Euroanaesthesia 2018
  • Int'l Joint Research
• [Presentation] オキシトシンによる妊娠ラット子宮筋収縮に対するプロポフォールとデクスメデトミジンの影響 (2017)
  • Author(s): 君塚基修
  • Organizer: 日本麻酔科学会第64回学術集会
• [Presentation] Influence of propofol and dexmedetomidine on oxytocin-induced contractions of isolated pregnant rat myometrium. (2017)
  • Author(s): 君塚基修
  • Organizer: Euroanaesthesia 2017
  • Int'l Joint Research