| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
We found that alternative splicing patterns were significantly altered in the primary sensory neurons of neuropathic pain model animals, and that alternative splicing abnormalities may contribute to the pathology of neuropathic pain. It was revealed that expression changes of lncRNA, which is a major regulator of alternative splicing, following nerve injury cause expression changes of various genes involved in inflammation and neural function. Furthermore, it was suggested that lncRNA may contribute to neuropathic pain by regulating intracellular localization of many splicing regulatory proteins in the primary sensory neurons via binding to them.
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