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Elucidation of molecular pathogenesis of interstitial cystitis based on microRNA expression signature

Research Project

Project/Area Number 17K16779
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionDokkyo Medical University

Principal Investigator

Fuse Miki  獨協医科大学, 医学部, 講師 (90568627)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords間質性膀胱炎 / マイクロRNA / miR-320 / 転写因子 / E2F-1 / E2F-2 / TUB / 間質性膀胱炎のマイクロRNA発現解析 / ゲノム
Outline of Final Research Achievements

We created the microRNA (miRNA) expression signature by using interstitial cystitis (IC) clinical specimens. Analysis of our signature revealed that a total of 366 miRNAs (203 downregulated and 163 upregulated) were aberrantly expressed in IC tissues. In particular, miR-320 family miRNAs (miR-320a, miR-320b, miR-320c, miR-320d and miR-320e) had downregulated expression in IC tissues. Genome-wide gene expression analyses and in silico database analyses showed that three transcription factors, E2F-1, E2F-2 and TUB, are regulated by miR-320 family miRNAs. Immunostaining of IC tissues confirmed that these transcription factors are overexpressed in IC tissues.

Academic Significance and Societal Importance of the Research Achievements

間質性膀胱炎は、原因不明の難治性膀胱炎であり、頻尿や痛みといった症状により患者のQOLを著しく低下させるが、いまだ客観的な診断法や有効な治療法がない難治性疾患である。本研究では、間質性膀胱炎の病態解明に向けて臨床検体におけるマイクロRNA発現プロファイルの作成し、間質性膀胱炎に関わる分子ネットワークの探索を行った。その結果、3つの転写因子(E2F-1, E2F-2, TUB)が間質性膀胱炎臨床検体において高発現している事を明らかにした。マイクロRNAを起点とした解析により、本疾患の分子病理学的理解が進む事が期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: MiR-320 family-regulated molecular pathways and targets2018

    • Author(s)
      Arai T, Fuse M, Goto Y, Kaga K, Kurozumi A, Yamada Y, Sugawara S, Okato A, Ichikawa T, Yamanishi T, Seki N.
    • Journal Title

      Journal of Human Genetics

      Volume: 63 Issue: 5 Pages: 543

    • DOI

      10.1038/s10038-018-0419-x

    • Related Report
      2019 Annual Research Report 2017 Research-status Report
    • Peer Reviewed

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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