| Project/Area Number |
17K16785
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
SHIMURA Hiroshi 山梨大学, 大学院総合研究部, 医学研究員 (70755842)
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| Research Collaborator |
TAKEDA MASAYUKI
MITSUI TAKAHIKO
KITAMURA KAZUO
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 光遺伝学 / Optogenetics / チャネルロドプシン / Fiber photometry / 下部尿路機能障害 / 前帯状回 / micturition / acc / optogenetics / electrical stimulation |
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| Outline of Final Research Achievements |
Fiberphotometry and optogenetics as novel technologies revealed regulatory function of the mouse anterior cingulate cortex in micturition reflex. The anterior cingulate cortex(ACC) has been speculated to be involved in urination from previous imaging studies.(Block,et al 1997) But the details are not well understood. We investigated the relationship between neural activity in ACC and urination using fiber photometry and optogenetics, which are new technologies using light. In conclusion, under urethane anesthesia, normal ACC neuronal activities are related to urination. The activity balance of the excitatory and inhibitory neurons of ACC may control urination.
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| Academic Significance and Societal Importance of the Research Achievements |
難治性過活動膀胱、難治性夜間頻尿、低活動膀胱、間質性膀胱炎などの発症頻度は加齢とともに増加している（日本排尿機能学会疫学調査、図）。過去２０年間に、過活動膀胱に対する抗コリン薬、交感神経系β３作動薬（以下β３作動薬）、前立腺肥大症に対する交感神経系α１受容体遮断薬（以下α１遮断薬）、PDE5阻害薬、５α還元酵素阻害薬などが開発され、いずれも臨床的なエビデンスは高く評価されている。難治性過活動膀胱に対しては、磁気刺激療法、ボツリヌス毒素膀胱壁内注入療法や仙髄神経電気刺激療法などの新規治療法があるが、これらに抵抗性の難治性過活動膀胱に対する有効な治療法は、存在しない。
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