New strategy for bladder cancer using atmospheric pressure plasma jet

• Project/Area Number: 17K16798
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kochi University
• Principal Investigator: FUKUHARA Hideo 高知大学, 教育研究部医療学系臨床医学部門, 助教 (20527600)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 膀胱癌 / プラズマ医療 / アポトーシス / 腫瘍学

Outline of Final Research Achievements

Atmospheric pressure plasmas jets kill cancer cell not only directly, but also indirectly affected cancer cell with plasma-irradiated medium. Medium which APPJs was irradiated generated the several biochemical activities. Plasma-activated medium (PAM) induces especially ROS generation by complicated chemical reactions into medium. ROS is well-known to activate apoptosis signal cascades for various cancer cells. PAM treatment may become a potential therapeutic strategy for human bladder cancer as intravesical therapy.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、プラズマを用いた新しい治療法により膀胱癌対する良好な効果を認めた。今後は更なるメカニズムを解明し、膀胱癌に対する新たな膀胱温存療法の開発が大いに期待される。

Research Products

• [Journal Article] Modelling the helium plasma jet delivery of reactive species into a 3D cancer tumour (2017)
  • Author(s): Szili Endre J、Oh Jun-Seok、Fukuhara Hideo、Bhatia Rishabh、Gaur Nishtha、Nguyen Cuong K、Hong Sung-Ha、Ito Satsuki、Ogawa Kotaro、Kawada Chiaki、Shuin Taro、Tsuda Masayuki、Furihata Mutsuo、Kurabayashi Atsushi、Furuta Hiroshi、Ito Masafumi、Inoue Keiji、Hatta Akimitsu、Short Robert D
  • Journal Title: Plasma Sources Science and Technology Volume: 27 Issue: 1 Pages: 014001-014001
  • DOI: 10.1088/1361-6595/aa9b3b
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Atmospheric pressure helium plasma for bladder cancer cells (2018)
  • Author(s): Hideo Fukuhara, Jun-Seok Oh, Endre Szili and Inoue Keiji
  • Organizer: 28Th Annual meeting of MRS-Japan 2018
  • Int'l Joint Research / Invited