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Complement activation mechanism by autoantigen recognition in benign prostatic hyperplasia

Research Project

Project/Area Number 17K16802
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionFukushima Medical University

Principal Investigator

Hata Junya  福島県立医科大学, 医学部, 助教 (00769606)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords前立腺肥大症 / 補体 / 自己抗原 / ラット / 自己免疫 / 免疫学
Outline of Final Research Achievements

Benign prostatic hyperplasia (BPH) is a common disease for elderly men and have various lower urinary tract symptoms such as dysuria and frequent urination. However, the mechanism of BPH remained unclear. In this study, we demonstrated that the activation of "complement component" which is one of the innate immune systems, is involved in the growth process of BPH. We also found that complement activation was associated with the presence of four molecules in the BPH tissues. Development of new therapeutic agents targeting this molecule is expected.

Academic Significance and Societal Importance of the Research Achievements

前立腺肥大症(BPH)の発症機序については、今まで男性ホルモンであるアンドロゲン、炎症、虚血などの関与が報告されてきたが、本研究は免疫系の一つである補体の関与を示した点で、独創性に満ちた研究と考えられる。現在、臨床の場では、既存の内服薬に抵抗性を示すBPH患者も多く存在する。そのような患者にとって、本研究の結果は、新たな治療標的の発見及び治療薬の開発に寄与するものであり、一つの光明を呈する成果と言える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia2019

    • Author(s)
      Hata Junya、Machida Takeshi、Matsuoka Kanako、Hoshi Seiji、Akaihata Hidenori、Hiraki Hiroyuki、Suzuki Toshiyuki、Ogawa Soichiro、Kataoka Masao、Haga Nobuhiro、Ishibashi Kei、Homma Yoshimi、Sekine Hideharu、Kojima Yoshiyuki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 00-00

    • DOI

      10.1038/s41598-019-57001-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Classical complement pathway activation mechanism in growth process of benign prostatic hyperplasia2018

    • Author(s)
      Junya Hata
    • Organizer
      International Continence Society 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Classical complement pathway activation mechanism in growth process of benign prostatic hyperplasia2018

    • Author(s)
      秦 淳也
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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