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Development of new treatment strategy for castration-resistant prostate cancer using a novel nuclear factor kappaB inhibitor

Research Project

Project/Area Number 17K16816
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionTokyo Medical University

Principal Investigator

HIRASAWA Yosuke  東京医科大学, 医学部, 助教 (10725310)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords前立腺癌 / 去勢抵抗性前立腺癌 / NFκB / FBP / cytotoxicity / inflammation / NFκB阻害 / CRPC / DU145 / 去勢抵抗性 / 癌 / 細胞・組織 / 核酸
Outline of Final Research Achievements

The aim of this project is to evaluate the efficacy of the novel NFκB inhibitors for castration-resistant prostate cancer, and it showed significant cytotoxic effects on DU145 cells and also proliferation-inhibiting effect against DU145 cells in subcutaneous tumor bearing mouse. The knockdown of Fuse-Binding Protein (FBP) by transfection method, which is well known as one of significant proteins for proliferation of many kinds of cancer, caused the proliferation-inhibiting effect for prostate cancer. It was showed that both of FBP and NFκB can be a therapeutic target for prostate cancer.

Academic Significance and Societal Importance of the Research Achievements

去勢抵抗性前立腺癌の予後は不良で、主にアンドロゲン遮断療法が施行されるが、次第にアンドロゲン非依存性増殖能を獲得し、治療抵抗性を示すいわゆる去勢抵抗性前立腺癌となる。ドセタキセルなどタキサン系抗がん剤は有用性が示されているが、予後改善の寄与度はわずか3か月-6か月程度であり、骨髄抑制など有害事象も無視できず新規治療戦略の確立は急務である。今回我々は、FBPとNFκBが共に去勢抵抗性前立腺癌細胞においても治療標的になり得ることを確認し、合成した新規NFκB阻害剤による新たな治療戦略の可能性を見出した。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Prognostic significance of the presence of tertiary Gleason grade 5 in robot-assisted radical prostatectomy specimens in Japanese patients with clinically localized prostate cancer2019

    • Author(s)
      Kamoda Naohiro、Ohori Makoto、Hirasawa Yosuke、Inoue Rie、Hashimoto Takeshi、Satake Naoya、Gondo Tatsuo、Nakagami Yoshihiro、Nagao Toshitaka、Ohno Yoshio
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 49 Issue: 3 Pages: 276-280

    • DOI

      10.1093/jjco/hyy194

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salvage radiation therapy for prostate cancer patients after prostatectomy2019

    • Author(s)
      Mima Takashi、Ohori Makoto、Hirasawa Yosuke、Mikami Ryuji、Arai Ayako、Hashimoto Takeshi、Satake Naoya、Gondo Tatsuo、Nakagami Yoshihiro、Namiki Kazunori、Tokuuye Koichi、Ohno Yoshio
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 49 Issue: 3 Pages: 281-286

    • DOI

      10.1093/jjco/hyy195

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostate-specific antigen screening impacts on biochemical recurrence in patients with clinically localized prostate cancer2018

    • Author(s)
      Hashimoto Takeshi、Ohori Makoto、Shimodaira Kenji、Kaburaki Naoto、Hirasawa Yosuke、Satake Naoya、Gondo Tatsuo、Nakagami Yoshihiro、Namiki Kazunori、Ohno Yoshio
    • Journal Title

      International Journal of Urology

      Volume: 25 Issue: 6 Pages: 561-567

    • DOI

      10.1111/iju.13563

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Impact of Lateral Bladder Neck Preservation on Urinary Continence Recovery After Robot-Assisted Radical Prostatectomy2018

    • Author(s)
      Hashimoto Takeshi、Yoshioka Kunihiko、Gondo Tatsuo、Hasama Kazuki、Hirasawa Yosuke、Nakashima Jun、Tachibana Masaaki、Ohno Yoshio
    • Journal Title

      Journal of Endourology

      Volume: 32 Issue: 1 Pages: 40-45

    • DOI

      10.1089/end.2017.0459

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] NCCN favourable intermediate-risk prostate cancer patients: Do all of them have a good prognosis?2019

    • Author(s)
      Ashita Ono, Yosuke Hirasawa, Syuya Matsubara, et al.
    • Organizer
      第34回 欧州泌尿器科学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NCCN予後中間リスク群は全て予後良好か?2019

    • Author(s)
      小野 朝、平澤 陽介、松原 修也、徳山 尚斗、橋本 剛、佐竹 直哉、権藤 立男、中神 義弘、並木 一典、中島 淳、大野 芳正
    • Organizer
      第107回 日本泌尿器科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Integration of neutrophil-to-lymphocyte ratio into the MD Anderson Cancer Center preoperative risk classification of patients with bladder cancer who underwent radical cystectomy2018

    • Author(s)
      Yosuke Hirasawa, Yuri Ishizawa, Tatsuo Gondo, et al.
    • Organizer
      第33回 欧州泌尿器科学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DEVELOPING A NEW PI-RADS V2-BASED PREOPERATIVE NOMOGRAM FOR PREDICTING THE PROBABILITY OF BIOCHEMICAL RECURRENCE AFTER ROBOT-ASSISTED RADICAL PROSTATECTOMY2018

    • Author(s)
      Naoto Kaburaki, Yosuke Hirasawa, Taiyo Harada, et al.
    • Organizer
      第113回 米国泌尿器科学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2020-03-30  

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