| Project/Area Number |
17K16835
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Hirose Asuka 東京医科歯科大学, 医学部附属病院, 助教 (10778468)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 産後うつ / 酸化ストレス / 抗酸化力 / エジンバラ産後うつ質問票 / dROM / BAP / 8-OHdG / d-ROM / 抗酸化物質 |
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| Outline of Final Research Achievements |
As a result of analysis of 84 women, the high score of the Edinburgh Postnatal Depression Scale (EPDS) in the second trimester and the low antioxidant marker were associated with the high EPDS in the first month after delivery. It was suggested that depressive symptoms in the second trimester and antioxidant activity immediately after delivery may be useful for predicting postpartum depression.
Furthermore, it was found that the oxidative marker was higher than that of healthy subjects from the second trimester to immediately after delivery. A sub-analysis of the relationships between oxidative stress and obstetric outcomes revealed that the fetal/placental weight ratio was lower in the high oxidative stress group. Placenta, which is abnormally heavy compared to the fetal weight, is said to be associated with neonatal death and fetal distress. It was thought that inadequate placentation caused hypoxia and increased oxidative stress, while the placenta became compensatory larger.
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| Academic Significance and Societal Importance of the Research Achievements |
産後うつ病は罹患率が10～15％と頻度が高く、子育てや児の成長発達へ大きな影響を与えるばかりでなく、自殺や児虐待の原因ともなり得る。産後うつ病の発症機構への酸化ストレスの関与に着目した研究はこれまでなかった。今回の研究結果から、妊娠中期のエジンバラ産後うつ質問票（EPDS）の点数の高さと抗酸化マーカーの低さが、産後1か月のEPDSの高さと関連することが明らかとなった。これにより、産後うつ病の予測に妊娠中期のうつ症状と分娩直後の抗酸化力が有用である可能性が示唆された。
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