| Project/Area Number |
17K16837
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Niigata University |
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Principal Investigator |
Adachi Sosuke 新潟大学, 医歯学総合病院, 助教 (50613147)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 子宮内膜症 / IL1A / 癌関連遺伝子変異 / 月経血逆流 / 疾患感受性遺伝子 / 癌関連遺伝子 |
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| Outline of Final Research Achievements |
We had previously clarified that IL1A was one of endometriosis susceptibility gene. In this study, we focused on IL1A to elucidate the pathogenesis of endometriosis. We performed whole exome sequencing for 13 endometriosis and 11 normal uterine endometrium samples. We did not find any somatic variants of IL1A in neither endometriosis nor normal uterine endometrium. However, we found frequently cancer-associated gene mutations such as PIK3CA or KRAS in both endometrioisis and normal uterine endometrium. As a result, we clarified that IL1A was endometriosis susceptibility gene but not driver gene in endometriosis.
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| Academic Significance and Societal Importance of the Research Achievements |
IL1Aが子宮内膜症のなりやすさに関連していることを明らかにし、また子宮内膜症と正常子宮内膜における遺伝子変異の類似性は、月経血の逆流によって子宮内膜組織が子宮外に正着し、子宮内膜症病変が形成されるという月経逆流説を支持しており、今後、子宮内膜症に対する新規治療法や予防法の開発につなげることができる。
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