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Significance of IL1A variants in endometriosis

Research Project

Project/Area Number 17K16837
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionNiigata University

Principal Investigator

Adachi Sosuke  新潟大学, 医歯学総合病院, 助教 (50613147)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords子宮内膜症 / IL1A / 癌関連遺伝子変異 / 月経血逆流 / 疾患感受性遺伝子 / 癌関連遺伝子
Outline of Final Research Achievements

We had previously clarified that IL1A was one of endometriosis susceptibility gene. In this study, we focused on IL1A to elucidate the pathogenesis of endometriosis. We performed whole exome sequencing for 13 endometriosis and 11 normal uterine endometrium samples. We did not find any somatic variants of IL1A in neither endometriosis nor normal uterine endometrium. However, we found frequently cancer-associated gene mutations such as PIK3CA or KRAS in both endometrioisis and normal uterine endometrium. As a result, we clarified that IL1A was endometriosis susceptibility gene but not driver gene in endometriosis.

Academic Significance and Societal Importance of the Research Achievements

IL1Aが子宮内膜症のなりやすさに関連していることを明らかにし、また子宮内膜症と正常子宮内膜における遺伝子変異の類似性は、月経血の逆流によって子宮内膜組織が子宮外に正着し、子宮内膜症病変が形成されるという月経逆流説を支持しており、今後、子宮内膜症に対する新規治療法や予防法の開発につなげることができる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2019 2017

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 5 results)

  • [Journal Article] Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients2019

    • Author(s)
      Sugino Kentaro、Tamura Ryo、Nakaoka Hirofumi、Yachida Nozomi、Yamaguchi Manako、Mori Yutaro、Yamawaki Kaoru、Suda Kazuaki、Ishiguro Tatsuya、Adachi Sosuke、Isobe Masanori、Yamaguchi Masayuki、Kashima Katsunori、Motoyama Teiichi、Inoue Ituro、Yoshihara Kosuke、Enomoto Takayuki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41598-019-54116-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium2019

    • Author(s)
      Suda Kazuaki、Nakaoka Hirofumi、Yoshihara Kosuke、Ishiguro Tatsuya、Adachi Sosuke、Kase Hiroaki、Motoyama Teiichi、Inoue Ituro、Enomoto Takayuki
    • Journal Title

      Human Reproduction

      Volume: 34 Issue: 10 Pages: 1899-1905

    • DOI

      10.1093/humrep/dez155

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer.2019

    • Author(s)
      Matsuo K, Cripe JC, Kurnit KC,Mikami M,SHida M,et al.
    • Journal Title

      Gynecol Oncol

      Volume: 155(1) Issue: 1 Pages: 39-50

    • DOI

      10.1016/j.ygyno.2019.08.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tumor characteristics and outcome of uterine carcinosarcoma in women aged 80 years.2019

    • Author(s)
      Matsuo K, Ross MS, Yunokawa M, Shida M,Mikami M,et al.
    • Journal Title

      Surg Oncol

      Volume: 29 Pages: 25-32

    • DOI

      10.1016/j.suronc.2019.02.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of statins, aspirin, and venous thromboembolism in women with endometrial cancer2019

    • Author(s)
      Matsuo Koji、Hom Marianne S.、Yabuno Akira、Shida Masako、Kakuda Mamoru、Adachi Sosuke、Mandelbaum Rachel S.、Ueda Yutaka、Hasegawa Kosei、Enomoto Takayuki、Mikami Mikio、Roman Lynda D.
    • Journal Title

      Gynecologic Oncology

      Volume: 152 Issue: 3 Pages: 605-611

    • DOI

      10.1016/j.ygyno.2018.12.020

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism2017

    • Author(s)
      Sapkota Y, Steinthorsdottir V, Morris AP, et al.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 15539-15539

    • DOI

      10.1038/ncomms15539

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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