| Project/Area Number |
17K16864
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 切迫早産 / 腸内細菌 / 制御性T細胞 / クロストリジウム / クロストリジウム属 |
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| Outline of Final Research Achievements |
We hypothesized that intestinal bacteria and the immune system are related to the pathogenesis of preterm labor, and analyzed the intestinal microbiota of pregnant women with threatened preterm labor (TPL). The results showed that the composition of the intestinal microbiota was different from that of normal pregnant women (NP). In the comparison of bacterial species, the abundance of several bacterial species significantly differed between two groups. We also established an assay system in which lymphocytes are analyzed by flow cytometry. Although the causes of preterm labor are diverse, it has been speculated that early preterm labor is associated with placental inflammation that is not caused by infection. The results of the study indicate that TPL women have a different gut microbiota from NP women. In the future, it is expected that the combination of intestinal microflora analysis and immune system analysis will lead to the elucidation of the pathogenesis of this disease.
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| Academic Significance and Societal Importance of the Research Achievements |
早産の原因は多様であるが、早期の流早産では感染症によらない胎盤の炎症が関連していることが推測されている。本研究の結果から切迫流早産妊婦は正常妊婦と異なる腸内細菌叢を有することが示された。腸内細菌叢の違いは免疫系や代謝系に影響を与えることが知られており、本疾患の病態にも影響を与えている可能性が示唆される。今後、腸内細菌叢解析と免疫系解析を組み合わせることにより本疾患の病態解明につながることが期待される。
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