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The development of method in detecting head and neck cancers using cancer-specific fluorescent probes

Research Project

Project/Area Number 17K16894
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

Fukuoka Osamu  東京大学, 医学部附属病院, 助教 (80779794)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords蛍光プローブ / GGT活性 / 頭頸部癌 / 蛍光イメージング / 頭頸部外科 / 頭頸部外科学
Outline of Final Research Achievements

The number of cases reacting to fluorescent probes targeting γ-glutamyltranspeptidase (GGT) in head and neck cancers was approximately 50%. On the other hand, RNA sequencing also revealed high expression of GGT1 and activation of PI3K pathway in half of the cases. The correlation of reaction to fluorescent probes and GGT1 expression was verified through cell experiment from head and neck cancers.

Academic Significance and Societal Importance of the Research Achievements

GGT1発現が発がんに深く関わるPI3Kシグナル伝達経路の下流で制御を受けることが示唆され、その阻害剤は将来的な新規治療薬としての可能性が期待される。GGT活性を確認するには本来免疫染色や遺伝子解析が必要だが、それを蛍光プローブという比較的簡便な手法で蛍光活性を評価する事で代用できればその意義は大きい。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (13 results)

All 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 濾胞癌の追加治療について,補完全摘とアブレーションの適応2019

    • Author(s)
      福岡修
    • Journal Title

      JOHNS

      Volume: 35 Pages: 713-715

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Clinical analysis of olfactory neuroblastoma2018

    • Author(s)
      明石 健, 福岡 修, 齊藤 祐毅, 安藤 瑞生, 吉田 昌史, 山岨 達也
    • Journal Title

      JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY

      Volume: 28 Issue: 1 Pages: 45-50

    • DOI

      10.5106/jjshns.28.45

    • NAID

      130007427793

    • ISSN
      1349-581X, 1884-474X
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Review of Head And Neck Cancer Patients with HIV Infection2018

    • Author(s)
      岡本 拓也, 齊藤 祐毅, 明石 健, 福岡 修, 吉田 昌史, 山岨 達也
    • Journal Title

      Nippon Jibiinkoka Gakkai Kaiho

      Volume: 121 Issue: 2 Pages: 127-133

    • DOI

      10.3950/jibiinkoka.121.127

    • NAID

      130006449170

    • ISSN
      0030-6622, 1883-0854
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma.2017

    • Author(s)
      Omura G, Ando M, Saito Y, Fukuoka O, Akashi K, Yoshida M, Kakigi A, Asakage T, Yamasoba T
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 印刷中 Issue: 3 Pages: 431-437

    • DOI

      10.1007/s10147-016-1076-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic value of lymphovascular invasion of the primary tumor in hypopharyngeal carcinoma after total laryngopharyngectomy2017

    • Author(s)
      Saito Yuki、Omura Go、Yasuhara Kazuo、Rikitake Ryoko、Akashi Ken、Fukuoka Osamu、Yoshida Masafumi、Ando Mizuo、Asakage Takahiro、Yamasoba Tatsuya
    • Journal Title

      Head & Neck

      Volume: 39 Issue: 8 Pages: 1535-1543

    • DOI

      10.1002/hed.24705

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma.2017

    • Author(s)
      Omura G, Ando M, Ebihara Y, Saito Y, Kobayashi K, Fukuoka O, Akashi K, Yoshida M, Asakage T, Yamasoba T.
    • Journal Title

      BMC Cancer.

      Volume: 17 Issue: 1 Pages: 898-898

    • DOI

      10.1186/s12885-017-3913-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Clinical outcome of nivolumab on recurrent or metastatic squamous cell carcinoma2019

    • Author(s)
      Osamu Fukuoka
    • Organizer
      Asia-Oceania ORL-HNS Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 当科におけるニボルマブ症例の検討2019

    • Author(s)
      福岡修
    • Organizer
      日本頭頸部外科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Clinical outcome of nivolumab on recurrent or metastatic squamous cell carcinoma2019

    • Author(s)
      Fukuoka O
    • Organizer
      Asia-Oceania ORL-HNS Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 当科におけるニボルマブ症例の検討2019

    • Author(s)
      福岡修
    • Organizer
      日本頭頸部外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 甲状腺微小癌の自然史とActive surveillanceのこれから2018

    • Author(s)
      福岡修
    • Organizer
      日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 当科における甲状腺乳頭癌高危険度群に対する治療の妥当性2018

    • Author(s)
      福岡修
    • Organizer
      日本頭頸部癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 当科において経験した乳腺相似分泌癌(MASC)症例2017

    • Author(s)
      福岡修、明石健、齊藤祐毅、吉田昌史、安藤瑞生、山岨達也
    • Organizer
      日本頭頸部癌学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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