The development of method in detecting head and neck cancers using cancer-specific fluorescent probes

• Project/Area Number: 17K16894
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: Fukuoka Osamu 東京大学, 医学部附属病院, 助教 (80779794)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 蛍光プローブ / GGT活性 / 頭頸部癌 / 蛍光イメージング / 頭頸部外科 / 頭頸部外科学

Outline of Final Research Achievements

The number of cases reacting to fluorescent probes targeting γ-glutamyltranspeptidase (GGT) in head and neck cancers was approximately 50%. On the other hand, RNA sequencing also revealed high expression of GGT1 and activation of PI3K pathway in half of the cases. The correlation of reaction to fluorescent probes and GGT1 expression was verified through cell experiment from head and neck cancers.

Academic Significance and Societal Importance of the Research Achievements

GGT1発現が発がんに深く関わるPI3Kシグナル伝達経路の下流で制御を受けることが示唆され、その阻害剤は将来的な新規治療薬としての可能性が期待される。GGT活性を確認するには本来免疫染色や遺伝子解析が必要だが、それを蛍光プローブという比較的簡便な手法で蛍光活性を評価する事で代用できればその意義は大きい。

Research Products

• [Journal Article] 濾胞癌の追加治療について，補完全摘とアブレーションの適応 (2019)
  • Author(s): 福岡修
  • Journal Title: JOHNS Volume: 35 Pages: 713-715
• [Journal Article] Clinical analysis of olfactory neuroblastoma (2018)
  • Author(s): 明石 健, 福岡 修, 齊藤 祐毅, 安藤 瑞生, 吉田 昌史, 山岨 達也
  • Journal Title: JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY Volume: 28 Issue: 1 Pages: 45-50
  • DOI: 10.5106/jjshns.28.45
  • NAID: 130007427793
  • ISSN: 1349-581X, 1884-474X
  • Peer Reviewed
• [Journal Article] A Review of Head And Neck Cancer Patients with HIV Infection (2018)
  • Author(s): 岡本 拓也, 齊藤 祐毅, 明石 健, 福岡 修, 吉田 昌史, 山岨 達也
  • Journal Title: Nippon Jibiinkoka Gakkai Kaiho Volume: 121 Issue: 2 Pages: 127-133
  • DOI: 10.3950/jibiinkoka.121.127
  • NAID: 130006449170
  • ISSN: 0030-6622, 1883-0854
  • Peer Reviewed
• [Journal Article] Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma. (2017)
  • Author(s): Omura G, Ando M, Saito Y, Fukuoka O, Akashi K, Yoshida M, Kakigi A, Asakage T, Yamasoba T
  • Journal Title: International Journal of Clinical Oncology Volume: 印刷中 Issue: 3 Pages: 431-437
  • DOI: 10.1007/s10147-016-1076-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of lymphovascular invasion of the primary tumor in hypopharyngeal carcinoma after total laryngopharyngectomy (2017)
  • Author(s): Saito Yuki、Omura Go、Yasuhara Kazuo、Rikitake Ryoko、Akashi Ken、Fukuoka Osamu、Yoshida Masafumi、Ando Mizuo、Asakage Takahiro、Yamasoba Tatsuya
  • Journal Title: Head & Neck Volume: 39 Issue: 8 Pages: 1535-1543
  • DOI: 10.1002/hed.24705
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma. (2017)
  • Author(s): Omura G, Ando M, Ebihara Y, Saito Y, Kobayashi K, Fukuoka O, Akashi K, Yoshida M, Asakage T, Yamasoba T.
  • Journal Title: BMC Cancer. Volume: 17 Issue: 1 Pages: 898-898
  • DOI: 10.1186/s12885-017-3913-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Clinical outcome of nivolumab on recurrent or metastatic squamous cell carcinoma (2019)
  • Author(s): Osamu Fukuoka
  • Organizer: Asia-Oceania ORL-HNS Congress
  • Int'l Joint Research
• [Presentation] 当科におけるニボルマブ症例の検討 (2019)
  • Author(s): 福岡修
  • Organizer: 日本頭頸部外科学会総会
• [Presentation] Clinical outcome of nivolumab on recurrent or metastatic squamous cell carcinoma (2019)
  • Author(s): Fukuoka O
  • Organizer: Asia-Oceania ORL-HNS Congress
  • Int'l Joint Research
• [Presentation] 当科におけるニボルマブ症例の検討 (2019)
  • Author(s): 福岡修
  • Organizer: 日本頭頸部外科学会
• [Presentation] 甲状腺微小癌の自然史とActive surveillanceのこれから (2018)
  • Author(s): 福岡修
  • Organizer: 日本外科学会定期学術集会
• [Presentation] 当科における甲状腺乳頭癌高危険度群に対する治療の妥当性 (2018)
  • Author(s): 福岡修
  • Organizer: 日本頭頸部癌学会
• [Presentation] 当科において経験した乳腺相似分泌癌(MASC)症例 (2017)
  • Author(s): 福岡修、明石健、齊藤祐毅、吉田昌史、安藤瑞生、山岨達也
  • Organizer: 日本頭頸部癌学会