| Project/Area Number |
17K16902
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 頭頸部癌 / FDG-PET/CT / Warburg効果 / M2マクロファージ / 腫瘍免疫 / がん代謝 / がん微小環境 / 機能イメージング / 乳酸 |
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| Outline of Final Research Achievements |
Fluorine-18 fluorodeoxyglucose uptake detected by positron emission tomography/computed tomography (FDG-PET/CT) is considered as a good indicator of aerobic glycolysis. In this study, whole-body FDG-PET/CT parameters; the maximum standardized uptake value (SUVmax) and mean SUV (SUVmean), were correlated with the C-reactive protein level, and neutrophil count. Furthermore, we investigated the relationships between FDG-PET/CT parameters and M2-macrophage polarization in head and neck squamous cell carcinoma (HNSCC) tissue. FDG-PET/CT has the potential to reflect cancer-related chronic inflammation and immunosuppressive conditions in cancer patients. FDG-PET/CT parameters appear to be useful in assessing the immune status in HNSCC.
Doppler ultrasound was used to measure blood flow in metastatic lymph nodes. Metastatic lymph nodes with decreased blood flow are related with decreased macrophage infiltration. This result was contrary to my hypothesis.
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| Academic Significance and Societal Importance of the Research Achievements |
解糖系が亢進（SUVmax、SUVmean が高値）している、つまりWarburg効果が亢進しているがんは、炎症が誘導され免疫抑制状態になっていると考えられた。炎症が誘導され免疫抑制状態になっているがんでは、治療抵抗性が高いと予想される。特に免疫チェックポイント阻害薬の治療効果に大きく関わるかもしれない。今回の結果は、FDG-PET/CTが、がん微小環境の免疫状態を反映することを示しており、将来的に免疫チェックポイント阻害薬などの治療効果を予測ツールとして使用が期待される。
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