| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
It is found in the visual cortex; a homeoprotein called Orthodenticle homeobox (Otx2) is transported specifically into parvalbumin (PV) inhibitory interneurons and play a crucial role in regulating cortical plasticity in the visual cortex by controlling both the onset and closure of the critical period of plasticity for visual sense. However, the roles of Otx2 in the auditory plasticity remain unclear. We generated conditional knockout mice of Otx2 and are analyzing the roles of Otx2 in auditory plasticity. we performed the comprehensive analysis from the cortex developmental point of view using RNA-Seq. In the future, we are planning to perform the functional analysis of these candidate genes.
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