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Investigation of roles of Otx2 homeoprotein in experience-dependent auditory plasticity

Research Project

Project/Area Number 17K16918
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionOkayama University

Principal Investigator

Edamatsu Midori  岡山大学, 医歯薬学総合研究科, 助教 (10735343)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords聴覚 / 神経科学 / 可塑性 / 臨界期
Outline of Final Research Achievements

It is found in the visual cortex; a homeoprotein called Orthodenticle homeobox (Otx2) is transported specifically into parvalbumin (PV) inhibitory interneurons and play a crucial role in regulating cortical plasticity in the visual cortex by controlling both the onset and closure of the critical period of plasticity for visual sense. However, the roles of Otx2 in the auditory plasticity remain unclear. We generated conditional knockout mice of Otx2 and are analyzing the roles of Otx2 in auditory plasticity. we performed the comprehensive analysis from the cortex developmental point of view using RNA-Seq. In the future, we are planning to perform the functional analysis of these candidate genes.

Academic Significance and Societal Importance of the Research Achievements

聴覚可塑性の仕組みが解明され,その開始を司る分子が明らかになれば,人工内耳の適用基準の改善や基準に新たな根拠を提供できる。さらに可塑性の再活性化が可能となれば,この原理をもとに人工内耳や聴性脳幹インプラントによる治療,リハビリテーションをさらに発展させることができる。本研究で可塑性のコントロールが可能になれば,将来的にはこのような聴神経や聴覚中枢の障害を修復し,脳の機能を再建する治療法の開発へも繋がる可能性を秘めている。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons2018

    • Author(s)
      Edamatsu Midori、Miyano Rinako、Fujikawa Atsushi、Fujii Fuminari、Hori Tetsuya、Sakaba Takeshi、Oohashi Toshitaka
    • Journal Title

      Journal of Neurochemistry

      Volume: 147 Issue: 6 Pages: 748-763

    • DOI

      10.1111/jnc.14571

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential localizations of the myo -inositol transporters HMIT and SMIT1 in the cochlear stria vascularis2018

    • Author(s)
      Edamatsu Midori、Kondo Yasuhiro、Ando Motonori
    • Journal Title

      Neuroscience Letters

      Volume: 674 Pages: 88-93

    • DOI

      10.1016/j.neulet.2018.03.028

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Functional role of the extracellular matrix molecule Hapln4/Bral2 at the calyx of Held synapse.2018

    • Author(s)
      Edamatsu M, Hori T, Oohashi T.
    • Organizer
      The 41th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2020-03-30  

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