| Project/Area Number |
17K16935
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 頭頚部癌 / 遠隔転移 / AP-1遺伝子群 / 頭頸部癌 / AP-1遺伝子 / JunB / 耳鼻咽喉科学 |
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| Outline of Final Research Achievements |
In order to find candidate factors affected by AP-1 family related to distant metastasis, we chose head and neck squamous cell carcinoma (HNSCC) cells which cause many lung metastases from among HNSCC cell held in our department,and performed proteome analysis that can be used to comprehensively analyze proteins using cells suppressed by siRNA JunB and FosL1 with control cells.Then, HMGA1 was identified as a candidate factor affected by AP-1 family. Similarly, we suppressed HMGA1 gene by siRNA HMGA1 and found that the migration ability of cells was decreased in suppressed cells.Therefore, we suggested that HMGA1 is one of genes involved in metastasis of HNSCC.
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| Academic Significance and Societal Importance of the Research Achievements |
頭頚部癌は鎖骨より頭側にある身体のうち，眼球と頭蓋内を除いた部位から発生する悪性腫瘍である．頭頚部は摂食や嚥下，構音などの生きていく上で欠かせない重要な部位であり，かつ見た目に大きく関わる部位であるため，手術で癌を取り除くことが容易でないことや顔面の形態が著しく変形するため，手術を希望されないことも多い．頭頸部癌の予後を大きく左右するのが，頸部リンパ節転移および肺転移であるため，転移を抑制するまたは，早期に転移を起こしやすい因子を発見することが頭頸部癌患者の予後を改善する重要な因子であると考える．その転移の原因を模索し，今後の新規治療法や新規診断法の開発に役立てることがこの研究の意義である．
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