| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Mutations in the RPE65 gene have been known to cause retinitis pigmentosa. To confirm the photoreceptor protective effects of 9-cis-retinal, we fed RPE65 knock-out mice by per os administration of 9-cis-retinal on postnatal 27 days old and checked whether we could find photoreceptor protective effects after administration of 9-cis-retinal using optical coherence tomography (OCT) and electroretinography (ERG). Results showed that although there was no morphological difference by OCT, there were statistically significant differences in the amplitudes of ERG a- and b-waves after 7 days of administration of 9-cis-retinal. The result indicated that administration of 9-cis-retinal has a therapeutic potential for retinitis pigmentosa caused by the mutations in the RPE65 gene.
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