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Development of a novel molecular targeted drug for diabetic wound using the inflammatory-related miR-129 family

Research Project

Project/Area Number 17K17021
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionNagasaki University

Principal Investigator

UMEHARA Takahiro  長崎大学, 医歯薬学総合研究科(医学系), 助教 (60617421)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords創傷治癒 / 好中球 / 糖尿病 / microRNA / circular RNA / micro RNA / 糖尿病性創傷 / 炎症
Outline of Final Research Achievements

Diabetes is known to delay wound healing and cause complications such as foot ulcers. We have previously shown that neutrophil retention in diabetic cutaneous wounds is aberrant in mice and inflammation is prolonged, and that this pathogenesis may result from dysfunction of diabetes-derived neutrophils.
To clarify the molecular mechanism that regulates inflammation in diabetes-derived neutrophils, we identified specific miRNAs (e.g. the miR-129 family) and their targeted mRNAs, and we analyzed the miRNA function. In this study, we clarified some functions of inflammation-related miRNAs and their target mRNAs using cellular and molecular biology.

Academic Significance and Societal Importance of the Research Achievements

慢性創傷の発症は糖尿病(DM)患者の15%に起こり、症例の80%以上で下肢の切断などQOLの低下をもたらす。従って、DM性創傷に対する治療法開発の要求度は社会的に高まっており、新規治療法の開発は急務であると考えられる。本研究は、新規治療薬開発への有用性が非常に高いmicroRNA(miRNA)に着目し、DM性創傷治癒過程におけるDM由来好中球の遺伝子発現制御機構の一端を解明した。これにより治癒促進効果のある新規分子標的治療薬開発へ展開するための基礎医学研究から臨床医学への還元が期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Identification of Specific miRNAs in Neutrophils of Type 2 Diabetic Mice: Overexpression of miRNA-129-2-3p Accelerates Diabetic Wound Healing.2019

    • Author(s)
      Umehara T, Mori R, Mace KA, Murase T, Abe Y, Yamamoto T, Ikematsu K
    • Journal Title

      Diabetes

      Volume: 68 Issue: 3 Pages: 617-630

    • DOI

      10.2337/db18-0313

    • NAID

      120006987788

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Identification of specific circular RNAs in diabetic-derived neutrophils2019

    • Author(s)
      Takahiro Umehara
    • Organizer
      Gordon research conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病由来好中球の炎症制御に関与するcircular RNAの同定2019

    • Author(s)
      梅原 敬弘
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of specific microRNA in diabetic-derived neutrophils: functional analysis of miR-129-2-3p in inflammation-related genes2018

    • Author(s)
      Takahiro Umehara
    • Organizer
      EMBL Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of specific microRNA in diabetic-derived neutrophils: overexpression of miR-129-2-3p accelerates diabetic wound healing.2018

    • Author(s)
      Takahiro Umehara
    • Organizer
      EMBO conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 2型糖尿病由来好中球特異的なmicroRNAの同定及び機能解2018

    • Author(s)
      梅原敬弘
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Identification of specific microRNAs in neutrophils of type 2 diabetic mice: functional analysis of miR-129-2-3p and inflammation-related genes2017

    • Author(s)
      梅原敬弘
    • Organizer
      Gordon Research Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of specific microRNAs in diabetic-derived neutrophils: functional analysis of miR-129-2-3p and inflammation-related genes2017

    • Author(s)
      梅原敬弘
    • Organizer
      33rd Ernst Klenk Symposium in Molecular Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of specific microRNAs in diabetic-derived neutrophils: functional analysis of miR-129-2-3p and inflammation-related genes2017

    • Author(s)
      梅原敬弘
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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