| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The association between human gut microbiome and immune system has been reported and attracted attention in various diseases. We previously reported the change of gut microbiota in the ICU patients may associate with infectious complications and prognosis. However, the background of these findings were unclear. The aim of this study was to explore the association between gut microbiome and immune system (cell-mediated immunity, humoral-mediated immunity and gut immunity) in the ICU patients. We revealed the correlations between the amount of endotoxin in feces and distibution of lymphocytes or the amount of immune globulin (IgA) in the blood. We also revealed the association between the amount of endotoxin in the feces and the amount of IgA in the feces. There were statistical differences in the amount of endotoxin and IgA in the feces and the distibution of lymphocytes between patients with diarrhea and without diarrhea.
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