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Does glucose fluctuations aggravate the prognosis of acute heart failure in diabetic patients

Research Project

Project/Area Number 17K17055
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionOita University

Principal Investigator

Saito Shotaro  大分大学, 医学部, 病院特任助教 (60631380)

Research Collaborator IKEBE Yuki  
SHIGA Ryosuke  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords糖尿病 / 心不全 / 血糖変動 / 急性心不全
Outline of Final Research Achievements

To assess the effect of glucose fluctuations for heart failure outcomes, we analyzed continuous glucose monitoring (CGM) records of heart failure patients with diabetes. The analysis of CGM records of patients without using diabetes drugs shows that over 80% patients spent the time at glucose < 80 mg/dL without symptoms. Longer time at glucose < 80 mg/dL and lower levels of glucose while using CGM were observed in patients with cardiomegaly. A more detailed analysis shows that correlations between time at glucose < 80 mg/dL and the levels of serum NT-proBNP are significant.

Academic Significance and Societal Importance of the Research Achievements

糖尿病は,近年血糖モニタリングシステムの発達によりより長時間の持続グルコース値測定が可能となり,食後高血糖や夜間低血糖などの血糖の大きな変動が,独立して予後に悪影響を与える可能性が示唆されている.心不全は,人口高齢化に伴い患者数が年々増加している.本研究では現在までの検討により,糖尿病合併心不全患者において,糖尿病治療薬の使用がない場合でも特に夜間から早朝に低血糖のリスクがあり、生命予後を悪化させる一因となる可能性が示唆された。社会的ニーズの高い糖尿病,心不全治療において,新たに着目すべき注意点となり得るため,引き続き研究を継続する.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Interleukin-10 treatment attenuates sinus node dysfunction caused by streptozotocin-induced hyperglycaemia in mice2018

    • Author(s)
      Kondo Hidekazu、Kira Shintaro、Oniki Takahiro、Gotoh Koro、Fukui Akira、Abe Ichitaro、Ikebe Yuki、Kawano Kyoko、Saito Shotaro、Aoki Kohei、Okada Norihiro、Nagano Yasuko、Akioka Hidefumi、Shinohara Tetsuji、Akiyoshi Kumiko、Masaki Takayuki、Teshima Yasushi、Yufu Kunio、Nakagawa Mikiko、Takahashi Naohiko
    • Journal Title

      Cardiovascular Research

      Volume: 115 Issue: 1 Pages: 57-70

    • DOI

      10.1093/cvr/cvy162

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Glucose Fluctuations Impair Cardiac Sinus Node Function in Diabetic Animal Models2017

    • Author(s)
      Ikebe Yuki
    • Organizer
      第81回日本循環器学会総会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Glucose Fluctuations Aggravate Cardiac Susceptibility to Ischemia/Reperfusion Injury by Modulating MicroRNAs Expression2017

    • Author(s)
      Saito Shotaro
    • Organizer
      第81回日本循環器学会総会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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