• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of medicine for improving salivation function by PAC1-R inhibitor

Research Project

Project/Area Number 17K17098
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionNational Institute of Health Sciences (2018)
Tokyo Dental College (2017)

Principal Investigator

TSUKAGOSHI ERI  国立医薬品食品衛生研究所, 医薬安全科学部, 任期付研究員 (60615384)

Research Collaborator MIURA tadashi  
TANABE koji  
OKUBO migiwa  
KOSUGE yasuhiro  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords口腔乾燥 / 精神疾患 / 抗不安薬 / ジアゼパム / レバミピド / 唾液腺 / 口腔乾燥症 / ベンゾジアゼピン受容体 / 薬理学 / 阻害薬
Outline of Final Research Achievements

In this study, we investigated whether rebamipide, an antistomach ulcer agent, ameliorated benzodiazepine-induced hyposalivation in rat parotid gland (PG) and submandibular gland (SMG). Repetitive administration of rebamipide reversed inhibitory effect of diazepam (DZP) on pilocarpine-induced salivary secretion. The present study has shown that rebamipide weakens the downregulatory effect of DZP on salivary secretion by preventing DZP-induced suppression of increase in [Ca2+]i. In addition, we examined the optimum concentration of rebamipide, and at the concentration that is safe for cultured salivary gland cells, inhibited the growth of bacteria against oral bacteria.

Academic Significance and Societal Importance of the Research Achievements

本研究は、精神性疾患患者に対して投与される抗不安薬が副作用として口腔乾燥症を発症することから、口腔状態を改善すべく唾液腺機能維持薬の開発を行うものである。本研究により、抗潰瘍薬のレバミピドが、抗不安薬投与下でも唾液分泌の抑制を抑えることができることを動物レベルで明らかにすることができた。レバミピドはすでに一般的に処方されている薬剤で、全身投与が一般的であるが、眼科領域ではすでに局所投与されている薬剤である。レバミピドを唾液腺にも応用し局所投与できるよう薬剤の開発が期待される。本研究により、唾液腺機能維持薬作製に向けて有効な結果が得られた。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2017

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results)

  • [Journal Article] Rebamipide, an anti-ulcerative drug, inhibits induction of salivary dysfunction by benzodiazepines2017

    • Author(s)
      Ogane M, Okubo M, Yoshikawa M, Shinomiya T, Tsukagoshi E, Kawaguchi M.
    • Journal Title

      Oral Diseases

      Volume: 23 Issue: 4 Pages: 511-517

    • DOI

      10.1111/odi.12642

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the nephrotoxicity in the mouse during repeated cisplatin (CDDP) treatments2017

    • Author(s)
      Yajima Y, Kawaguchi M, Yoshikawa M, Okubo M, Tsukagoshi E, Sato K, Katakura A.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 134 Issue: 2 Pages: 108-115

    • DOI

      10.1016/j.jphs.2017.05.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Effect of Dexamethasone on the Proliferation and Osteoblastic Differentiation of Human Mesenchymal Stem Cells Treated with Fluvastatin2017

    • Author(s)
      Tanabe K, Miura T, Yang L, Tsukagoshi E, Yoshinari M, Kasahara M.
    • Journal Title

      Journal of Oral Tissue Engineering

      Volume: 14 Issue: 3 Pages: 151-156

    • DOI

      10.11223/jarde.14.151

    • NAID

      130006394673

    • ISSN
      1348-9623, 1880-0823
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2017-04-28   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi