| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Tumor vascular endothelial cells have acquired various abnormalities as compared with normal vascular endothelial cells. The mechanism of the acquisition of the anomaly is often unknown. Tumor tissue is in a hypoxic environment, and it has been suggested that this hypoxic environment may affect normal vascular endothelial cells. We have also found that reactive oxygen species (ROS) may play an important role in the mechanism. The behavior of normal vascular endothelial cells under hypoxia was further investigated.
It was suggested that aneuploidy was observed in normal vascular endothelial cells cultured under hypoxic condition, which may cause chromosomal abnormality.In addition, under the conditions, it behaved similarly to the gene expression changes observed in tumor vascular endothelial cells. The positional relationship between aneuploid vascular endothelial cells and hypoxic sites in tumor tissues was clarified.
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