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Study of new Endodontic treatment using LIPUS target for Inflammasome

Research Project

Project/Area Number 17K17116
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionTohoku University

Principal Investigator

Suto Mizuki  東北大学, 大学病院, 医員 (40708046)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsインフラマソーム / LIPUS / マクロファージ / 抗炎症作用 / 抗炎症
Outline of Final Research Achievements

Low-intensity pulsed ultrasound (LIPUS), which acts on cells as a mechanical stress, has been reported that LIPUS treatment has a potential to activate osteogenesis. However, little is known regarding an effect of LIPUS treatment on inflammation. In this study, we examined the effect of LIPUS on J774.1, a murine macrophage cell line, stimulated with E. coli lipopolysaccharide (LPS). We found that LIPUS exerts anti-inflammatory effects on LPS-stimulated J774.1 by inhibiting NF-κB signaling, resulting in an inhibition of IL-1β expression. LIPUS may be a powerful therapeutic tool for the NF-κB-associated diseases such as periodontal diseases.

Academic Significance and Societal Importance of the Research Achievements

LIPUS照射のLPS刺激したマウスマクロファージ様株化細胞に与える影響について検討した結果、LIPUS照射はLPSが誘導したIL-1βの発現を遺伝子およびタンパクレベルで抑制した。これはインフラマソーム情報伝達経路に影響を及ぼすものではなくNFκ-Bのp65シグナルを抑制することによってIL-1βの発現を抑制するものと示唆された。これらの知見はLIPUS照射がNFκ-Bに関与する疾患の治療法に対して有効に作用する可能性を示唆するものと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (11 results)

  • [Journal Article] Cyclic stretch force induces periodontal ligament cells to secrete exosomes that suppress IL-1β production through the inhibition of the NF-κB signaling pathway in macrophages.2019

    • Author(s)
      Wang Z, Maruyama K, Sakisaka Y, Suzuki S, Tada H, Suto M, Saito M, Yamada S, Nemoto E
    • Journal Title

      Front Immunol,

      Volume: ecollection Pages: 01310-01310

    • DOI

      10.3389/fimmu.2019.01310

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclic Stretch Negatively Regulates IL-1β Secretion Through the Inhibition of NLRP3 Inflammasome Activation by Attenuating the AMP Kinase Pathway2018

    • Author(s)
      Maruyama K, Sakisaka Y, Suto M, Tada H, Nakamura T, Yamada S, Nemoto E.
    • Journal Title

      Front. Physiol.

      Volume: 9 Pages: 802-802

    • DOI

      10.3389/fphys.2018.00802

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular calcium increases fibroblast growth factor 2 gene expression via extracellular signal-regulated kinase 1/2 and protein kinase A signaling in mouse dental papilla cells2018

    • Author(s)
      Kanaya Sousuke、Xiao Binlu、Sakisaka Yukihiko、Suto Mizuki、Maruyama Kentaro、Saito Masahiro、Nemoto Eiji
    • Journal Title

      Journal of Applied Oral Science

      Volume: 26 Issue: 0 Pages: 231-241

    • DOI

      10.1590/1678-7757-2017-0231

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Evaluation of the Clinical Effectiveness of a Vibrating Scaler Using an Electric Rotating Mass for Removing Calculus2017

    • Author(s)
      丸山顕太郎、池野修好、小松秀裕、向阪幸彦、大方広志、須藤瑞樹、根本英二、庄司茂
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 60 Issue: 3 Pages: 111-119

    • DOI

      10.11471/shikahozon.60.111

    • NAID

      130006946816

    • ISSN
      0387-2343, 2188-0808
    • Related Report
      2017 Research-status Report
  • [Presentation] 後天性てんかんを有する広汎型重度慢性歯周炎患者に対する早期インプラント埋入を含めた包括 的歯周治療を行った一症例2019

    • Author(s)
      須藤瑞樹、根本英二、島内英俊、山田聡
    • Organizer
      第62回春季歯周病学会 日本歯周病学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 広汎型重度慢性歯周炎患者に対しリグロスを用いた歯周組織再生療法を行い、 包括的歯科治療を行った一症例2019

    • Author(s)
      須藤瑞樹、山田聡
    • Organizer
      第151回秋季日本歯科保存学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒト歯根膜細胞は周期的伸展刺激により抗炎症性エクソソームを分泌する2018

    • Author(s)
      王祝愉、根本英二、丸山顕太郎、鈴木茂樹、多田浩之、向阪幸彦、須藤瑞樹、山田聡
    • Organizer
      第61回秋季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 骨補填材を用いたGBRにおける純チタン製メンブレンの有効性ついて2018

    • Author(s)
      石幡浩志、須藤瑞樹、向阪幸彦、小松秀裕、丸山顕太郎、山田聡、 長谷川博
    • Organizer
      第61回秋季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規GBR用純チタン製メンブレンの有用性ついて:βTCPを用いたin vivoでの評価2018

    • Author(s)
      須藤瑞樹、石幡浩志、向阪幸彦、山田聡、長谷川博
    • Organizer
      第61回秋季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] in vivoでの新規GBR用純チタン製メンブレンの有効性ついて2018

    • Author(s)
      向阪幸彦、石幡浩志、須藤瑞樹、小松秀裕、丸山顕太郎、山田聡、 長谷川博
    • Organizer
      第61回秋季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] LIPUS inhibits IL-1β secretion through NF-κB signaling pathway in macrophages2018

    • Author(s)
      Mizuki Suto, Eiji Nemoto, Kentaro Maruyama, Yukihiko Sakisaka, Satoru Yamada
    • Organizer
      第104回アメリカ歯周病学会共催 カナダ歯周病学会・日本臨床歯周病学会・ 日本歯周病学会 2018年大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Cyclic stretch inhibits IL-1β secretion by attenuating NLRP3 inflammasome activation2018

    • Author(s)
      Eiji Nemoto , Kentaro Maruyama , Yukihiko Sakisaka , Mizuki Suto , Hiroyuki Tada , Takashi Nakamura , Satoru Yamada
    • Organizer
      第104回アメリカ歯周病学会共催 カナダ歯周病学会・日本臨床歯周病学会・ 日本歯周病学会 2018年大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Low-intensity pulsed ultrasound (LIPUS) inhibits proinflamatory cytokine secretion from murine macrophages triggered by E.coli Lipopolsaccharide.2017

    • Author(s)
      Mizuki Suto、Kentaro Maruyama、Sousuke Kanaya、Eiji Nemoto
    • Organizer
      The 2017 Japan-NIH Joint Symposium.
    • Related Report
      2017 Research-status Report
  • [Presentation] LIPUS刺激はNF-κBシグナル抑制を介してIL-1β分泌を抑制する2017

    • Author(s)
      須藤瑞樹、丸山顕太郎、金谷聡介、根本英二
    • Organizer
      第146回秋季日本歯科保存学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] マクロファージ周期的伸展刺激はNLRP3インフラマソームを介したIL-1β分泌を抑制する2017

    • Author(s)
      丸山顕太郎、須藤瑞樹、向阪幸彦、金谷聡介、根本英二
    • Organizer
      第146回秋季日本歯科保存学会学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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