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The effect of new reducing agent on discoloration by silver diamine fluoride

Research Project

Project/Area Number 17K17124
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Matsui Naoko  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (10754963)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsフッ化ジアンミン銀 / 象牙質
Outline of Final Research Achievements

In order to deal with root caries in a super-aging society, we pursued the possibility of clinical application of a new reducing agent in combination with silver diamine fluoride (SDF) to tooth surface. A new reducing agent (glutathione) or potassium iodide was mixed with SDF, and the discoloration suppressing effect, antibacterial property, demineralization suppressing effect and biofilm adhesion were verified.
For the results, the discoloration due to SDF changes depending on the concentration, and the method of using a reducing agent in combination with SDF application to suppress discoloration has the effect of suppressing discoloration, but the effect of suppressing decalcification and the effect of suppressing biofilm adhesion. Was suggested to be inferior to conventional SDF application alone.

Academic Significance and Societal Importance of the Research Achievements

近年の超高齢社会を迎えた我が国は中・高年者の保有歯数の増加に伴い、露出根面に発生する“根面う蝕”の急増が問題となっている。高齢者・要介護者の根面う蝕の1次予防処置としてフッ化ジアンミン銀(以下SDFと記載)の歯根面への塗布の有効性が高く評価されている。本研究はSDF塗布による黒変という欠点を改善し、SDFのより幅広い応用と高齢者・要介護者のQOL向上に大いに貢献するものと考えられる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2021 2019 2018 2017

All Journal Article (9 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Effects of Universal Adhesives on Dentin Adhesive Performance and Acid-base Resistance2021

    • Author(s)
      Ryuta ANDO, Takaaki SATO, Naoko MATSUI, Masaomi IKEDA, Noriko HIRAISHI, Tomohiro TAKAGAKI, Toru NIKAIDO, Junji TAGAMI, Yasushi SHIMADA
    • Journal Title

      Operative Dentistry, Endodontology and Periodontology

      Volume: 1 Issue: 1 Pages: 88-96

    • DOI

      10.11471/odep.2021-012

    • NAID

      130008138565

    • ISSN
      2436-4975
    • Year and Date
      2021-12-31
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of silver diamine fluoride preparations on biofilm formation of <i>Streptococcus mutans </i>2021

    • Author(s)
      TAKAHASHI Motoi、MATIN Khairul、MATSUI Naoko、SHIMIZU Miyuki、TSUDA Yuka、UCHINUMA Shigeki、HIRAISHI Noriko、NIKAIDO Toru、TAGAMI Junji
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 4 Pages: 911-917

    • DOI

      10.4012/dmj.2020-341

    • NAID

      130008069848

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-07-25
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Micro-CT assessment of the effect of silver diammine fluoride on inhibition of root dentin demineralization2021

    • Author(s)
      SHIMIZU Miyuki、MATSUI Naoko、SAYED Mahmoud、HAMBA Hidenori、OBAYASHI Sho、TAKAHASHI Motoi、TSUDA Yuka、TAKAGAKI Tomohiro、NIKAIDO Toru、TAGAMI Junji
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 4 Pages: 1041-1048

    • DOI

      10.4012/dmj.2020-290

    • NAID

      130008069746

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-07-25
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of discoloration of sound/demineralized root dentin with silver diamine fluoride: <i>In-vitro</i> study2019

    • Author(s)
      Sayed M, Matsui N, Hiraishi N, Inoue G, Nikaido T, Burrow MF, Tagami J
    • Journal Title

      Dental Materials Journal

      Volume: 38 Issue: 1 Pages: 143-149

    • DOI

      10.4012/dmj.2018-008

    • NAID

      130007592580

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2019-01-28
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Office Bleaching on Enamel Bonding Performance.2019

    • Author(s)
      Halabi S, Matsui N, Nikaido T, Burrow MF, Tagami J.
    • Journal Title

      J Adhes Dent

      Volume: 21(2) Pages: 167-177

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of fluoride mouthrinse and fluoride concentration on bonding of a one-step self-etch adhesive to bovine root dentin2019

    • Author(s)
      Nakamoto A, Sato T, Matsui N, Ikeda M, Nikaido T, Burrow MF, Tagami J.
    • Journal Title

      Journal of Oral Science

      Volume: 61 Issue: 1 Pages: 125-132

    • DOI

      10.2334/josnusd.17-0466

    • NAID

      130007626632

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of Different Tooth Conditioners on the Bonding of Universal Self-etching Adhesive to Dentin2019

    • Author(s)
      Sato T, Takagaki T, Baba Y, Vicheva M, Matsui N, Hiraishi N, Ikeda M, Nikaido T, Tagami J
    • Journal Title

      J Adhes Dent

      Volume: 21(1) Pages: 77-85

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of MDP and NaF in Two-step Self-etch Adhesives on Enamel Microshear Bond Strength and Morphology of the Adhesive-Enamel Interface.2018

    • Author(s)
      Kakiuchi Y, Takagaki T, Ikeda M, Sato T, Matsui N, Nikaido T, Burrow MF, Tagami J
    • Journal Title

      J Adhes Dent

      Volume: 20(6) Pages: 527-534

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride2018

    • Author(s)
      Sayed Mahmoud、Matsui Naoko、Hiraishi Noriko、Nikaido Toru、Burrow Michael、Tagami Junji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 5 Pages: 1322-1322

    • DOI

      10.3390/ijms19051322

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Effect of Glutathione on Tooth Discoloration With Silver Diamine Fluoride2018

    • Author(s)
      Sayed Mahmoud, Matsui Naoko, Hiraishi Noriko, Nikaido Toru, Tagami Junji
    • Organizer
      IADR/PER General Session (London, England)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of Office Bleaching on Enamel Bonding Performance2018

    • Author(s)
      Halabi Somayah, Matsui Naoko, Nikaido Toru, Tagami Junji
    • Organizer
      IADR/PER General Session (London, England)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of Silver Diamine Fluoride Application on Dentin Bonding Performance2018

    • Author(s)
      Ko Ko Aye, Matsui Naoko, Nikaido Toru, Nakamoto Ayako, Ikeda Masaomi, Tagami Junji
    • Organizer
      IADR/PER General Session (London, England)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] フッ化ジアンミン銀系材料塗布後の歯根面におけるバイオフィルム形成の評価2018

    • Author(s)
      髙橋基、松井七生子、マティンカイルール、清水美透、平石典子、二階堂徹、田上順次
    • Organizer
      日本歯科保存学会秋季学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Micro-CTを用いたフッ化ジアンミン銀系材料の歯根面象牙質脱灰抑制効果の評価2018

    • Author(s)
      清水美透、松井七生子、半場秀典、大林翔、マハムドサイド、髙橋基、二階堂徹、田上順次
    • Organizer
      日本歯科保存学会秋季学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] フッ化ジアンミン銀による脱灰象牙質の変色の評価2017

    • Author(s)
      マハムド サイド
    • Organizer
      第147回日本歯科保存学会2017年度秋季学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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