Improvement of resin-dentin bond durability by removing water from dentinal collagen

• Project/Area Number: 17K17125
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Chiba Ayaka 東京医科歯科大学, 歯学部, 非常勤講師 (90778911)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 象牙質コラーゲン / 水 / 歯質接着性レジン / 酸エッチング / 接着システム / 接着性レジン / コラーゲン / レジン / 自由水 / 間隙 / 浸透 / 歯質接着耐久性 / 象牙質 / 脂質接着耐久性 / 有機溶媒 / 象牙質接着耐久性 / エタノール / 歯学

Outline of Final Research Achievements

In the adhesive system containing the hydrophilic monomer HEMA (2-Hydroxyethyl Methacrylate), in etch and rinse mode, ethanol wet bonding technique instead of water wet bonding technique may promote monomer infiltration and significantly improved the adhesive strength. It is suggested that the ethanol-soluble dimethacrylate can infiltrate, and the resin-dentin adhesion durability can be achieved considerably. In addition, it was confirmed that pretreatment with an antioxidant containing sulfinate salt improved the degree of conversion of adhesive and contribute to resin-dentin bond durability.

Academic Significance and Societal Importance of the Research Achievements

低侵襲歯科治療が普及し直接法コンポジットレジン接着修復が臨床上広く用いられるようになってきているが，コンポジットレジンが臨床上十分な，物性，審美性を兼ね備えてきた一方で，治療の成功を支える接着は発展途上であり，接着の劣化がおこるため接着耐久性は十分とは考えられていない。本研究は，劣化を起こす水による影響を低減しよりよい長期にわたり機能する象牙質接着を獲得するため，ジメタクリレートの浸透と硬化という接着に必須のステップおいて改良する接着技法を提案しよりよい接着治療につなげるものである。

Research Products

• [Int'l Joint Research] チェンマイ大学(タイ)
• [Int'l Joint Research] チャールズ大学(チェコ)
• [Int'l Joint Research] ロンドン大学(英国)
• [Int'l Joint Research] チェンマイ大学(タイ)
• [Int'l Joint Research] ロンドン大学(英国)
• [Int'l Joint Research] チェンマイ大学/バンコクトンブリ大学(タイ)
• [Int'l Joint Research] ロンドン大学(英国)
• [Int'l Joint Research] ロンドン大学(英国)
• [Int'l Joint Research] チェンマイ大学/チョンブリ大学(タイ)
• [Journal Article] Degree of conversion and dentin bond strength of light-cured multi-mode adhesives pretreated or mixed with sulfinate agents (2021)
  • Author(s): Hasegawa M, Tichy A, Hosaka K, Kuno Y, Ikeda M, Nozaki K, Chiba A, Nakajima M, Tagami J.
  • Journal Title: Dental Materials Journal Volume: 40 Issue: 4 Pages: 877-884
  • DOI: 10.4012/dmj.2020-346
  • NAID: 130008069861
  • ISSN: 0287-4547, 1881-1361
  • Year and Date: 2021-07-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of central and peripheral dentin on micro-tensile bond strength estimated using a competing risk model. (2020)
  • Author(s): Tichy A, Brabec M, Bradna P, Hosaka K, Chiba A, Tagami J.
  • Journal Title: J Mech Behav Biomed Mater Volume: 115 Pages: 104295-104295
  • DOI: 10.1016/j.jmbbm.2020.104295
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The combined effect of light-illuminating direction and enamel rod orientation on color adjustment at the enamel borders of composite restorations (2019)
  • Author(s): Hatayama Takashi、Kano Yukinori、Aida Asami、Chiba Ayaka、Sato Kento、Seki Naoko、Hosaka Keiichi、Foxton Richard M.、Tagami Junji、Nakajima Masatoshi
  • Journal Title: Clinical Oral Investigations Volume: 38 Issue: 7 Pages: 2305-2313
  • DOI: 10.1007/s00784-019-03085-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stress distribution in tooth resin core build-ups with different post-end positions in alveolar bone level under two kinds of load directions (2018)
  • Author(s): HATAYAMA Takashi、CHIBA Ayaka、KAINOSE Kimisuke、NAKAJIMA Masatoshi、HOSAKA Keiichi、WAKABAYASHI Noriyuki、FOXTON Richard M.、TAGAMI Junji
  • Journal Title: Dental Materials Journal Volume: 37 Issue: 3 Pages: 474-483
  • DOI: 10.4012/dmj.2017-160
  • NAID: 130007394745
  • ISSN: 0287-4547, 1881-1361
  • Year and Date: 2018-05-28
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The strategies used for curing universal adhesives affect the micro-bond strength of resin cement used to lute indirect resin composites to human dentin (2018)
  • Author(s): Daisuke Araoka, Keiichi Hosaka, Masatoshi Nakajima, Richard Foxton, Thanatvarakorn Ornnicha, Prasansuttiporn Taweesak, Ayaka Yoshimine, Kento Sato, Masahiro Takahashi, Masayuki Otsuki, Junji Tagami.
  • Journal Title: Dental Materials Journal Volume: 37 Issue: 3 Pages: 506-514
  • DOI: 10.4012/dmj.2017-240
  • NAID: 130007394724
  • ISSN: 0287-4547, 1881-1361
  • Year and Date: 2018-05-28
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Color adaptation at enamel-composite borders with different incidnet-light directions. (2018)
  • Author(s): Masatoshi Nakajima, Kano Yukinori, Asami Aida, Ayaka Chiba, Keiichi Hosaka, Naoko Seki, Richard Foxton, Taweesak Pransansuttiporn, Ornnicha Thanatvarakorn, Junji Tagami.
  • Organizer: 96th IADR/PER General Session
  • Int'l Joint Research
• [Presentation] マルチモード接着システムの象牙質接着性能に及ぼすデュアルキュアアクティベーター前塗布の影響 (2018)
  • Author(s): 長谷川 真夕(東京医科歯科大学 大学院医歯学総合研究科う蝕制御学分野), 千葉 彩香, 久野 裕介, 荒岡 大輔, 佐藤 健人, 保坂 啓一, 池田 正臣, 中島 正俊, 田上 順次
  • Organizer: 第149回日本歯科保存学会
• [Presentation] ポスト先端部と歯槽骨（皮質骨・海綿骨）の位置関係と荷重方向の違いがレジンコア築造歯の応力分布に与える影響. (2017)
  • Author(s): 畑山貴志、千葉彩香、貝ノ瀬公典、中島正俊、保坂啓一、若林則幸、田上順次.
  • Organizer: 第146回日本歯科保存学会学術大会