| Project/Area Number |
17K17156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Candida albicans / 義歯性口内炎 / 慢性萎縮性カンジダ症 / Candida / デンチャープラーク / カンジダ症 / バイオマテリアル |
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| Outline of Final Research Achievements |
The aim of this study is to develop the methods of removing C. albicans on denture materials and treating oral candidiasis. We showed that the adhesion of C. albicans is reduced by the incorporation of the S-PRG filler in the tissue conditioner. In addition, we investigated that the optimal amount of filler by measuring the consistency, penetration depth, and surface roughness. We were supposed to investigate the effect of the filler on other microorganisms and do the clinical test, but I could not do because I took maternity leave.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題では，臨床応用に向けた臨床試験までは完了できなかったものの，義歯粘膜調整剤に抗菌性フィラーであるS-PRGフィラーを添加し，そのC. albicansに対する抗菌効果および最適なフィラー添加量の検証を行うことができた．現在急増している誤嚥性肺炎の一因にC. albicansの関与もあることから，同フィラーを用いた抗菌義歯用材料開発の社会的意義は大きいものと考えられる．
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