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Longitudinal assessment of large-scale MRI data for elucidation of pathological progression mechanism of temporomandibular disorders

Research Project

Project/Area Number 17K17165
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionOsaka University

Principal Investigator

Takaoka Ryota  大阪大学, 歯学部附属病院, 医員 (20733968)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords顎関節症 / 変形性顎関節症 / 関節円板側方転位 / Subchondral cyst / MRI / 縦断研究 / subchondral cyst / 顎関節円板側方転位 / 顎関節内障 / MR / 大規模データ / joint effusion / 歯学
Outline of Final Research Achievements

The present study longitudinally investigated subchondral cyst (SC) in temporomandibular joint (TMJ). Based on the result, SCs tended to form in anterosuperior and central parts of the condyle where mechanical loading was likely to be applied. SCs were strongly associated with abnormal joint disc position. In addition, two-thirds of SCs resolved over time, accompanying the resorption and deformation of the condyle and eminence.
The present study also had observed sideways disc displacement in 23 TMJs for 4-9 years by using MRI. This longitudinal study revealed that in some TMJs, the degree of sideways displacement changed, but there was no case in which the sideway displacement changed to the anterior disc displacement

Academic Significance and Societal Importance of the Research Achievements

Subchondral cyst(SC)は変形性顎関節症と診断される決定的な画像所見であるにもかかわらずその病態は明らかになっていない.本研究において顎関節円板転位がSCの発生条件の一つであることが明らかとなり,またSCを有する患者は保存療法のみでも安定した経過を辿ることが明らかとなった.また,関節円板側方転位の病態も明らかではなかったが,本縦断研究により,円板側方転位は円板前方転位とは異なるメカニズムで発症し,独自の経過を辿る可能性が示唆された.

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2021 2020 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Relative risk of positional and dynamic temporomandibular disc abnormality for osteoarthritis-magnetic resonance imaging study2021

    • Author(s)
      Takaoka Ryota、Yatani Hirofumi、Senzaki Yuki、Koishi Yukiko、Moriguchi Daisuke、Ishigaki Shoichi
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 48 Issue: 4 Pages: 375-383

    • DOI

      10.1111/joor.13138

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] 顎関節症のテーラーメイド医療に向けたMRIの応用-変形性顎関節症の遺伝的リスク因子の探索-2020

    • Author(s)
      高岡亮太
    • Organizer
      第33回日本顎関節学会学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] MRIを用いた変形性顎関節症患者におけるsubchondral cystの縦断研究2020

    • Author(s)
      小石由紀子,高岡亮太,内山百夏,中谷温紀,島本博彰,久山晃太郎,林 暁雨,森口大輔,玉利秀樹,桑原俊也,石垣尚一,矢谷博文
    • Organizer
      第33回日本顎関節学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Elucidation of pathophysiology with a longitudinal study of subchondral cyst utilizing MR images in TMD patients.2019

    • Author(s)
      Koishi Y,Takaoka R,Moriguchi D, Lin X, Kuyama K, Kayashima H, Shimamoto H,Nakatani A, Uchiyama Y, Ishigaki S, Yatani H
    • Organizer
      18th International College of Prosthodontics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRIを用いた顎関節内障の三次元的評価 第一報:関節円板転移の三次元的分類.2019

    • Author(s)
      高岡亮太, 仙崎勇輝,林暁雨,小石由紀子,森口大輔,鈴木英史,奥田眞夫,石垣尚一,矢谷博文.
    • Organizer
      日本補綴歯科学会 第128回学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] MRIを用いた顎関節内障の三次元的評価 第二報:joint effusion像.2019

    • Author(s)
      仙崎勇輝,高岡亮太,林暁雨,小石由紀子,森口大輔,鈴木英史,奥田眞夫,石垣尚一,矢谷博文.
    • Organizer
      日本補綴歯科学会 第128回学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] MRIを用いた顎関節症患者における subchondral cystの横断研究.2019

    • Author(s)
      小石由紀子,高岡亮太, 林暁雨,久山晃太郎,仙崎勇輝,玉利秀樹,桑原俊也,島本博彰,中谷温紀,内山百夏,石垣尚一,矢谷博文.
    • Organizer
      第32回日本顎関節学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Clinical Evaluation of Dynamic Quantitative Sensory Testing for the Assessment of Central Sensitization.2019

    • Author(s)
      Moriguchi D, Ishigaki S, Yatani H, Lin X, Kuyama K, Koishi Y, Takaoka R
    • Organizer
      19th Asian Academy of Orofacial Pain and Temporomandibular Disorders (AAOT) Scientific Meeting on "NON-ODONTOGENIC OROFACIAL PAIN"
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRIデータを用いたjoint effusionと関節円板の位置,動態および下顎頭骨変化との関連2018

    • Author(s)
      仙崎勇輝,高岡亮太,森口大輔,小石由紀子,林 暁雨,玉利秀樹,桑原俊也,石垣尚一,矢谷博文
    • Organizer
      日本顎関節学会
    • Related Report
      2018 Research-status Report
  • [Presentation] MRIデータを用いたjoint effusionと関節円板の位置,動態および下顎頭骨変化との関連2018

    • Author(s)
      仙崎勇輝,高岡亮太,森口大輔,小石由紀子,林 暁雨,玉利秀樹,桑原俊也,石垣尚一,矢谷博文
    • Organizer
      第31回日本顎関節学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] MRIデータを用いた顎関節内障とjoint effusionの関連についての予備調査2017

    • Author(s)
      仙崎勇輝,高岡亮太,桑原俊也,石垣尚一,矢谷博文
    • Organizer
      第30回日本顎関節学会学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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