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Innovation for dry mouth treatment that aimes prevention of oral frailty in patients with prosthodontic treatment.

Research Project

Project/Area Number 17K17184
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKyushu Dental College

Principal Investigator

KONDO YUSUKE  九州歯科大学, 歯学部, 助教 (00611287)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔乾燥症 / 唾液腺 / 老化 / 加齢 / フレイル / オーラルフレイル
Outline of Final Research Achievements

Aging affect a lot of tissues and cells, however, the aging effect on salivary gland function still remains controversial and unclear. This study aimed to evaluate the effects of aging on mouse parotid and submandibular gland function to gain insight into the association between aging and salivary gland function using Senescence accelerated mouse. Results of this study demonstrate that aged SMG function was diminished, and cell senescent, chronic inflammation and decreased gene expression of AQP5 could be proposed as the cause of hyposalivation in aged mouse SMG.

Academic Significance and Societal Importance of the Research Achievements

口腔乾燥症はカリエスリスクの上昇,歯周病の増悪,嚥下障害や構音障害,義歯の装着困難など口腔環境に影響を及ぼし補綴歯科治療のリスク因子となる.義歯やクラウン,ブリッジ,インプラントなどが適切に機能していても口腔乾燥症の発症によりその機能は大きく失われる.既に超高齢社会の到来している本邦において, 加齢による口腔乾燥症は超高齢社会において今後さらに患者数が増加するにもかかわらずその原因は不明であった. 本研究で得られた結果は, そのメカニズム解明にとって重要なブレークスルーとなり, 今後の治療方法開発に寄与するものと考えられる.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Submandibular gland-specific inflammaging-induced hyposalivation in the male senescence-accelerated mouse prone -1?line (SAM-P1)2019

    • Author(s)
      Miyagi Yuta、Kondo Yusuke、Kusuda Yuichiro、Hori Yusuke、Yamazaki Seiya、Munemasa Takashi、Mukaibo Taro、Masaki Chihiro、Hosokawa Ryuji
    • Journal Title

      Biogerontology

      Volume: 印刷中 Issue: 4 Pages: 421-432

    • DOI

      10.1007/s10522-019-09797-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 老化が唾液腺機能へ及ぼす影響について2018

    • Author(s)
      宮城勇大,近藤祐介,堀裕亮,宗政翔,向坊太郎,正木千尋,細川隆司
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Aging affects muscarinic agonist-induced fluid secretion from submandibular gland2018

    • Author(s)
      Miyagi Y, Kondo Y, Kusuda Y, Hori Y, Tsuka S, Mukaibo T, Masaki C, Hosokawa R
    • Organizer
      The 96th General Session & Exhibition of the IADR
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 老化促進マウスにおける唾液分泌能の解析2017

    • Author(s)
      宮城勇大,近藤祐介,楠田優一郎,宗政翔,堀裕亮,向坊太郎,柄慎太郎,田村暁子,青沼史子,正木千尋,細川隆司
    • Organizer
      平成29年度公益社団法人日本補綴歯科学会九州支部学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of novel treatment for dry mouth - preliminary animal studies -2017

    • Author(s)
      Kondo Y, Munemasa T, Mukaibo T, Tsuka S, Masaki C and Hosokawa R
    • Organizer
      2017 BIENNIAL JOINT CONGRESS OF CPS-JPS-KAP.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2020-03-30  

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