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Comprehensive analysis of the antiadhesive action of 2-methacryloyloxyethyl phosphorylcholine coating on an acrylic resin denture base material

Research Project

Project/Area Number 17K17188
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionShowa University

Principal Investigator

TAKAHASHI NANA  昭和大学, 歯学部, 助教 (80635061)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsMPC / 義歯 / デンチャープラーク / バイオマテリアル / 歯学 / バイオフィルム
Outline of Final Research Achievements

We have been conducting research to prevent bacterial growth by coating 2-methacryloyloxyethyl phosphoryl choline (MPC) polymer on dentures with the aim of developing "clean dentures". In this application, analysis of bacterial species in the plaque adhering to the dentures of 22 people wearing the maxillary full dentures and those changes before and after MPC coating were mainly performed.
As a result, there were many facultative anaerobes in denture plaque as well as in the plaque adhering to the teeth, and the causative bacteria of aspiration pneumonia were also detected in all the subjects. Moreover, it turned out that there is no change of the bacterial species in the denture plaque before and after coating, and that the coating is less likely to cause disease.

Academic Significance and Societal Importance of the Research Achievements

我々はこれまでにも2-メタクリロイルオキシエチルホスホリルコリン(MPC)ポリマーを義歯(入れ歯)にコーティングし、”汚れない義歯”の開発を目指してきた。その際には1種類の口腔内細菌を選択し、それに対してのMPCポリマーの効果を分析していた。
今回のように実際の義歯に付着する細菌類をまず特定し、それらに対してのMPCポリマーの働き(例えば特定の菌への効果の有無等)をみることができたことは、今後のMPCポリマーの臨床応用へ向けた貴重なデータとなりうると言える。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2018

All Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Analysis of bacterial flora in denture plaque by NGS2018

    • Author(s)
      Tsukahara A, Ikeya K, Iwasa F, Morisaki H, Fukunishi M, Takahashi N, Kuwata H, Baba K
    • Organizer
      International Association for Dental Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] デンチャープラーク細菌叢の16S rRNAメタゲノム解析2018

    • Author(s)
      塚原明弘,池谷賢二,岩佐文則,福西美弥,久志本那奈,馬場一美
    • Organizer
      日本老年歯科医学会 第29回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 次世代シークエンサーによるデンチャープラーク細菌叢の解析2018

    • Author(s)
      塚原明弘,池谷賢二,岩佐文則,森崎弘史,福西美弥,高橋那奈,桑田啓貴,馬場一美
    • Organizer
      日本補綴歯科学会 第8回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 次世代シークエンサーによるデンチャープラーク細菌叢の解析2018

    • Author(s)
      塚原明弘,池谷賢二,岩佐文則,森崎弘史,福西美弥,高橋那奈,桑田啓貴,馬場一美
    • Organizer
      日本補綴歯科学会第127回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] デンチャープラーク細菌叢の16S rRNAメタゲノム解析2018

    • Author(s)
      塚原明弘,池谷賢二,岩佐文則,福西美弥,久志本那奈,馬場一美
    • Organizer
      日本老年歯科医学会第29回学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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