Formulating of clinical diagnostic criteria for sleep bruxism

• Project/Area Number: 17K17190
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Showa University
• Principal Investigator: Yoshida Yuya 昭和大学, 歯学部, 助教 (60783298)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 睡眠時ブラキシズム / 臨床徴候 / PSG / 睡眠ポリグラフ検査 / グラインディング / クレンチング / 睡眠歯科医学 / 臨床診断 / 睡眠ポリグラフィ / 歯科補綴学 / 睡眠医学

Outline of Final Research Achievements

Sleep bruxism (SB) is defined as: ‘an oral parafunction characterized by grinding or clenching of the teeth during sleep that is associated with an excessive (intense) sleep arousal activity’. Clinical diagnosis of SB is generally made based on information gathered through medical interviews and clinical examinations, such as reports of tooth-grinding sounds during sleep, orodental findings such as tooth attrition, morning symptoms of masticatory muscle pain, fatigue or stiffness and masseter muscle hypertrophy. One important question is whether these signs and symptoms represent SB accurately. To answer this question, we investigated the associations between masseter muscle activity patterns during sleep and clinical diagnostic criteria for sleep bruxism(SB).

Academic Significance and Societal Importance of the Research Achievements

睡眠時ブラキシズム(SB)は，睡眠中の非機能的な顎運動であり，顎口腔系の諸器官に様々な悪影響を及ぼし，補綴歯科領域における患者のQuality of lifeの低下を招く原因である．本研究は，チェアサイドより収集されるSBの臨床情報と睡眠ポリグラフ検査(PSG)を用いることで得られるSBの生理学的病態との関連性を明らかにすることで，患者個々の筋活動状態を反映した症型分類に基づく臨床診断法の確立を目指し，個別化医療を実践するためのものである.

Research Products

• [Journal Article] 睡眠時ブラキシズム －治療予後向上のための理論と実践－ (2019)
  • Author(s): 馬場一美，吉田裕哉
  • Journal Title: Innovative Zahanmedizin Volume: - Pages: 6-17
• [Journal Article] Effects of a contingent vibratory stimulus delivered by an intra-oral device on sleep bruxism: a pilot study (2019)
  • Author(s): Nakamura Hirotaka、Takaba Masayuki、Abe Yuka、Yoshizawa Shuichiro、Suganuma Takeshi、Yoshida Yuya、Nakazato Yukari、Ono Yasuhiro、Clark Glenn T.、Baba Kazuyoshi
  • Journal Title: Sleep and Breathing Volume: 23 Issue: 1 Pages: 363-372
  • DOI: 10.1007/s11325-019-01782-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Generation of neural cells using iPSCs from sleep bruxism patients with 5-HT2A polymorphism (2017)
  • Author(s): Hoashi Y, Okamoto S, Abe Y, Matsumoto T, Tanaka J, Yoshida Y, Imaizumi K, Mishima K, Akamatsu W, Okano H, Baba K
  • Journal Title: Journal of Prosthodontic Research Volume: 61 Issue: 3 Pages: 242-250
  • DOI: 10.1016/j.jpor.2016.11.003
  • NAID: 130006076280
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed
• [Presentation] 睡眠時ブラキシズムに対する振動刺激を用いた長期的抑制効果の予備的検証． (2019)
  • Author(s): 小原大宜, 中里友香理, 青木理紗, 吉田裕哉, 高場雅之, 安部友佳, 菅沼岳史, 馬場一美
  • Organizer: 日本顎口腔機能学会第63回学術大会
• [Presentation] 携帯型睡眠検査装置による睡眠時ブラキシズム記録の妥当性検証 (2018)
  • Author(s): 中里友香理，高場雅之，吉田裕哉，安部友佳，葭澤秀一郎，中村浩崇，川名ふさ江，菅沼岳史，加藤隆史，矢谷博文，馬場一美
  • Organizer: 日本顎口腔機能学会 第60回学術大会
• [Presentation] Accuracy of Online Symptom Checker on Orofacial Pain and Oral Medicine Disease (2018)
  • Author(s): Yuya Yoshida, Glenn Clark
  • Organizer: American academy of orofacial pain 42nd Scientific Meeting
  • Int'l Joint Research
• [Presentation] 簡易睡眠検査装置による睡眠時ブラキシズムの測定 (2017)
  • Author(s): 中里友香理，高場雅之，吉田裕哉，安部友佳，小野康寛，葭澤秀一郎，中村浩崇，菅沼岳史，馬場一美
  • Organizer: 第30回日本顎関節学会総会・学術大会 第22回日本口腔顔面痛学会学術大会
• [Presentation] Accuracy of newly developed portable PSG device for detection of sleep bruxism-related masseter EMG muscle activity. (2017)
  • Author(s): Nakazato Y，Takaba M，Yoshida Y，Abe Y，Ono Y，Yoshizawa S，Nakamura H，Kawana F，Suganuma T，Kato T，Baba K
  • Organizer: 14th World Sleep 2017 A JOINT CONGRESS OF WORLD ASSOCIATION OF SLEEP MEDICINE AND WORLD SLEEP FEDERATION
  • Int'l Joint Research